This HTML5 document contains 90 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n26http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n14http://linked.opendata.cz/resource/AHFS/
foafhttp://xmlns.com/foaf/0.1/
n20http://linked.opendata.cz/resource/drugbank/company/
n9http://linked.opendata.cz/resource/mesh/concept/
n19http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/chemspider/
n15http://linked.opendata.cz/resource/drugbank/dosage/
n18http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/chebi/
n32http://bio2rdf.org/drugbank:
n13http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/wikipedia/
n28http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/pharmgkb/
admshttp://www.w3.org/ns/adms#
n30http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/kegg-compound/
n21http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/bindingdb/
n4http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n29http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/pubchem-compound/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n27http://linked.opendata.cz/resource/drugbank/medicinal-product/
n7http://linked.opendata.cz/ontology/drugbank/
n8http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n17http://www.drugs.com/cdi/
n6http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/pubchem-substance/
n10http://linked.opendata.cz/resource/drugbank/property/
n24http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/iuphar/
n25http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/drugbank/
xsdhhttp://www.w3.org/2001/XMLSchema#
n23http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/guide-to-pharmacology/
n12http://linked.opendata.cz/resource/atc/
n31http://linked.opendata.cz/resource/drugbank/drug/DB01064/identifier/national-drug-code-directory/
n11http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01064
rdf:type
n7:Drug
n7:description
Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. [PubChem]
n7:dosage
n15:271B5DAE-363D-11E5-9242-09173F13E4C5
n7:group
approved
n7:indication
For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis
owl:sameAs
n4:DB01064 n32:DB01064
dcterms:title
Isoprenaline
adms:identifier
n6:46507323 n13:Isoproterenol n18:64317 n19:3647 n21:25392 n23:536 n24:536 n25:DB01064 n28:PA450121 n29:3779 n30:C07056 n31:0089-0785-21
n7:mechanismOfAction
The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
n7:packager
n20:271B5DA9-363D-11E5-9242-09173F13E4C5 n20:271B5DAA-363D-11E5-9242-09173F13E4C5 n20:271B5DA7-363D-11E5-9242-09173F13E4C5 n20:271B5DA8-363D-11E5-9242-09173F13E4C5
n7:routeOfElimination
Excretion following inhalation administration is primarily renal and the major metabolite is the sulfate conjugate of isoproterenol.
n7:synonym
N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine Isoprenalina N-isopropyl-β-dihydroxyphenyl-β-hydroxyethylamine Isoproterenol Isoprenalinum (+-)-Isoproterenol (±)-isoproterenol N-Isopropylnorepinephrine (+-)-Isoprenaline (±)-isoprenaline N-Isopropylnoradrenaline Isoprenaline 3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol Isopropyl noradrenaline α-(isopropylaminomethyl)protocatechuyl alcohol alpha-(Isopropylaminomethyl)protocatechuyl alcohol 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol
n11:hasAHFSCode
n14:12-12-08-04 n14:52-92-00 n14:84-04-12 n14:84-04-92
n7:salt
n7:synthesisReference
U.S. Patent 2,308,232. U.S. Patent 2,715,141.
n8:hasConcept
n9:M0011781
foaf:page
n17:isoproterenol.html n26:isoproterenol.htm
n7:IUPAC-Name
n10:271B5DB3-363D-11E5-9242-09173F13E4C5
n7:InChI
n10:271B5DB9-363D-11E5-9242-09173F13E4C5
n7:Molecular-Formula
n10:271B5DB8-363D-11E5-9242-09173F13E4C5
n7:Molecular-Weight
n10:271B5DB5-363D-11E5-9242-09173F13E4C5
n7:Monoisotopic-Weight
n10:271B5DB6-363D-11E5-9242-09173F13E4C5
n7:SMILES
n10:271B5DB7-363D-11E5-9242-09173F13E4C5
n7:Water-Solubility
n10:271B5DB1-363D-11E5-9242-09173F13E4C5
n7:logP
n10:271B5DB2-363D-11E5-9242-09173F13E4C5 n10:271B5DCA-363D-11E5-9242-09173F13E4C5 n10:271B5DAF-363D-11E5-9242-09173F13E4C5
n7:logS
n10:271B5DB0-363D-11E5-9242-09173F13E4C5
n11:hasATCCode
n12:C01CA02 n12:R03CB01 n12:R03AB02
n7:H-Bond-Acceptor-Count
n10:271B5DBF-363D-11E5-9242-09173F13E4C5
n7:H-Bond-Donor-Count
n10:271B5DC0-363D-11E5-9242-09173F13E4C5
n7:InChIKey
n10:271B5DBA-363D-11E5-9242-09173F13E4C5
n7:Polar-Surface-Area--PSA-
n10:271B5DBB-363D-11E5-9242-09173F13E4C5
n7:Polarizability
n10:271B5DBD-363D-11E5-9242-09173F13E4C5
n7:Refractivity
n10:271B5DBC-363D-11E5-9242-09173F13E4C5
n7:Rotatable-Bond-Count
n10:271B5DBE-363D-11E5-9242-09173F13E4C5
n7:affectedOrganism
Humans and other mammals
n7:casRegistryNumber
7683-59-2
n7:category
n7:containedIn
n27:271B5DAD-363D-11E5-9242-09173F13E4C5 n27:271B5DAB-363D-11E5-9242-09173F13E4C5 n27:271B5DAC-363D-11E5-9242-09173F13E4C5
n7:Bioavailability
n10:271B5DC5-363D-11E5-9242-09173F13E4C5
n7:Ghose-Filter
n10:271B5DC7-363D-11E5-9242-09173F13E4C5
n7:MDDR-Like-Rule
n10:271B5DC8-363D-11E5-9242-09173F13E4C5
n7:Melting-Point
n10:271B5DC9-363D-11E5-9242-09173F13E4C5
n7:Number-of-Rings
n10:271B5DC4-363D-11E5-9242-09173F13E4C5
n7:Physiological-Charge
n10:271B5DC3-363D-11E5-9242-09173F13E4C5
n7:Rule-of-Five
n10:271B5DC6-363D-11E5-9242-09173F13E4C5
n7:Traditional-IUPAC-Name
n10:271B5DB4-363D-11E5-9242-09173F13E4C5
n7:pKa--strongest-acidic-
n10:271B5DC1-363D-11E5-9242-09173F13E4C5
n7:pKa--strongest-basic-
n10:271B5DC2-363D-11E5-9242-09173F13E4C5