This HTML5 document contains 52 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00944/identifier/wikipedia/
dctermshttp://purl.org/dc/terms/
n17http://linked.opendata.cz/resource/drugbank/drug/DB00944/identifier/pharmgkb/
foafhttp://xmlns.com/foaf/0.1/
n23http://linked.opendata.cz/resource/drugbank/company/
n10http://linked.opendata.cz/resource/mesh/concept/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00944/identifier/pubchem-compound/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00944/identifier/pubchem-substance/
n8http://bio2rdf.org/drugbank:
n22http://linked.opendata.cz/resource/drugbank/drug/DB00944/identifier/kegg-drug/
n21http://linked.opendata.cz/resource/drugbank/drug/DB00944/identifier/drugbank/
admshttp://www.w3.org/ns/adms#
n20http://www.drugs.com/mtm/
n6http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n9http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n19http://www.rxlist.com/cgi/generic2/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n15http://linked.opendata.cz/resource/atc/
n14http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00944
rdf:type
n3:Drug
n3:description
Demecarium is an indirect-acting parasympathomimetic agent that is used to treat glaucoma. It is a cholinesterase inhibitor or an anticholinesterase. Cholinesterase inhibitors prolong the effect of acetylcholine, which is released at the neuroeffector junction of parasympathetic postganglion nerves, by inactivating the cholinesterases that break it down. Demecarium inactivates both pseudocholinesterase and acetylcholinesterase. In the eye, this causes constriction of the iris sphincter muscle (causing miosis) and the ciliary muscle. The outflow of the aqueous humor is facilitated, which leads to a reduction in intraocular pressure.
n3:generalReferences
# Ward DA, Abney K, Oliver JW: The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12641839 # Krohne SG: Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs. Am J Vet Res. 1994 Dec;55(12):1729-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7887518 # Gum GG, Gelatt KN, Gelatt JK, Jones R: Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8430939
n3:group
approved
n3:indication
For the topical treatment of chronic open-angle glaucoma.
owl:sameAs
n6:DB00944 n8:DB00944
dcterms:title
Demecarium
adms:identifier
n12:46507824 n13:5965 n16:Demecarium_bromide n17:PA164745610 n21:DB00944 n22:D00667
n3:mechanismOfAction
Demecarium is an indirect-acting parasympathomimetic agent, also known as a cholinesterase inhibitor and anticholinesterase. Cholinesterase inhibitors prolong the effect of acetylcholine, which is released at the neuroeffector junction of parasympathetic postganglion nerves, by inactivating the cholinesterases that break it down. Demecarium inactivates both pseudocholinesterase and acetylcholinesterase. In the eye, this causes constriction of the iris sphincter muscle (causing miosis) and the ciliary muscle (affecting the accommodation reflex and causing a spasm of the focus to near vision). The outflow of the aqueous humor is facilitated, which leads to a reduction in intraocular pressure. Of the two actions, the effect on the accommodation reflex is the more transient and generally disappears before termination of the miosis.
n3:packager
n23:271B3FC3-363D-11E5-9242-09173F13E4C5
n3:synonym
Demecarium
n3:toxicity
The oral LD<sub>50</sub> is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.
n3:salt
n3:synthesisReference
Schrnid, O.; US. Patent 2,789,981; April 23, 1957; assigned to Oesterreichische Stickstoffwerke AG, Austria.
n9:hasConcept
n10:M0424412
foaf:page
n19:demecarium.htm n20:demecarium-bromide-ophthalmic.html
n3:IUPAC-Name
n4:271B3FC8-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B3FCE-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B3FCD-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3FCA-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B3FCB-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B3FCC-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B3FC6-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B3FDD-363D-11E5-9242-09173F13E4C5 n4:271B3FC7-363D-11E5-9242-09173F13E4C5 n4:271B3FC4-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B3FC5-363D-11E5-9242-09173F13E4C5
n14:hasATCCode
n15:S01EB04
n3:H-Bond-Acceptor-Count
n4:271B3FD4-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B3FD5-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B3FCF-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B3FD0-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B3FD2-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B3FD1-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B3FD3-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:category
n3:Bioavailability
n4:271B3FD8-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B3FDA-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B3FDB-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B3FDC-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B3FD7-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B3FD6-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B3FD9-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B3FC9-363D-11E5-9242-09173F13E4C5