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Namespace Prefixes

PrefixIRI
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n11http://linked.opendata.cz/resource/drugbank/drug/DB00880/identifier/pharmgkb/
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n4http://linked.opendata.cz/resource/drugbank/company/
n23http://linked.opendata.cz/resource/drugbank/dosage/
n6http://linked.opendata.cz/resource/drugbank/drug/DB00880/identifier/pubchem-compound/
n22http://linked.opendata.cz/resource/drugbank/mixture/
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n26http://linked.opendata.cz/resource/drugbank/drug/DB00880/identifier/drugbank/
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n8http://linked.opendata.cz/resource/drugbank/drug/DB00880/identifier/national-drug-code-directory/
n30http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
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n3http://linked.opendata.cz/ontology/drugbank/
n14http://www.drugs.com/cdi/
n13http://www.rxlist.com/cgi/generic2/
n27http://linked.opendata.cz/resource/drugbank/drug/DB00880/identifier/chebi/
n9http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n21http://linked.opendata.cz/resource/atc/
n29http://linked.opendata.cz/resource/drugbank/drug/DB00880/identifier/wikipedia/
n20http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00880
rdf:type
n3:Drug
n3:description
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
n3:dosage
n23:271B566D-363D-11E5-9242-09173F13E4C5 n23:271B566E-363D-11E5-9242-09173F13E4C5 n23:271B566F-363D-11E5-9242-09173F13E4C5 n23:271B5670-363D-11E5-9242-09173F13E4C5 n23:271B5671-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
45-120 minutes
n3:indication
Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
n3:manufacturer
n4:271B565E-363D-11E5-9242-09173F13E4C5 n4:271B5665-363D-11E5-9242-09173F13E4C5 n4:271B5666-363D-11E5-9242-09173F13E4C5 n4:271B5663-363D-11E5-9242-09173F13E4C5 n4:271B5664-363D-11E5-9242-09173F13E4C5 n4:271B5661-363D-11E5-9242-09173F13E4C5 n4:271B5662-363D-11E5-9242-09173F13E4C5 n4:271B565F-363D-11E5-9242-09173F13E4C5 n4:271B5660-363D-11E5-9242-09173F13E4C5
owl:sameAs
n16:DB00880 n30:DB00880
dcterms:title
Chlorothiazide
adms:identifier
n6:2720 n7:46507032 n8:0378-0150-01 n11:PA448953 n24:C07461 n25:D00519 n26:DB00880 n27:3640 n28:2619 n29:Chlorothiazide
n3:mechanismOfAction
As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
n3:packager
n4:271B5659-363D-11E5-9242-09173F13E4C5 n4:271B565A-363D-11E5-9242-09173F13E4C5 n4:271B5657-363D-11E5-9242-09173F13E4C5 n4:271B5658-363D-11E5-9242-09173F13E4C5 n4:271B565D-363D-11E5-9242-09173F13E4C5 n4:271B565B-363D-11E5-9242-09173F13E4C5 n4:271B565C-363D-11E5-9242-09173F13E4C5 n4:271B5651-363D-11E5-9242-09173F13E4C5 n4:271B5652-363D-11E5-9242-09173F13E4C5 n4:271B564F-363D-11E5-9242-09173F13E4C5 n4:271B5650-363D-11E5-9242-09173F13E4C5 n4:271B5655-363D-11E5-9242-09173F13E4C5 n4:271B5656-363D-11E5-9242-09173F13E4C5 n4:271B5653-363D-11E5-9242-09173F13E4C5 n4:271B5654-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
Chlorothiazide is not metabolized but is eliminated rapidly by the kidney. After oral doses, 10 to 15 percent of the dose is excreted unchanged in the urine. Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.
n3:synonym
Chlorothiazide Chlorthiazide Clorotiazida 6-chloro-7-Sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide Chlorothiazid Uroflux 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide Mechlozid Chlorothiazidum
n3:toxicity
Oral, rat LD<sub>50</sub>: > 10 g/kg. Signs of overdose include those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered hypokalemia may accentuate cardiac arrhythmias.
n3:mixture
n22:271B564D-363D-11E5-9242-09173F13E4C5 n22:271B564E-363D-11E5-9242-09173F13E4C5
n3:proteinBinding
Approximately 40% bound to plasma proteins.
n3:salt
n3:synthesisReference
Eugene S. Barabas, "Water soluble complex of a poly (vinyl lactam) and chlorothiazide and process for producing same." U.S. Patent US4713238, issued December, 1985.
n18:hasConcept
n19:M0004186
foaf:page
n13:chloroth.htm n14:chlorothiazide.html
n3:IUPAC-Name
n9:271B5676-363D-11E5-9242-09173F13E4C5
n3:InChI
n9:271B567C-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n9:271B567B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n9:271B5678-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n9:271B5679-363D-11E5-9242-09173F13E4C5
n3:SMILES
n9:271B567A-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n9:271B568C-363D-11E5-9242-09173F13E4C5 n9:271B5674-363D-11E5-9242-09173F13E4C5
n3:logP
n9:271B568E-363D-11E5-9242-09173F13E4C5 n9:271B5672-363D-11E5-9242-09173F13E4C5 n9:271B5675-363D-11E5-9242-09173F13E4C5
n3:logS
n9:271B568F-363D-11E5-9242-09173F13E4C5 n9:271B5673-363D-11E5-9242-09173F13E4C5
n3:pKa
n9:271B5691-363D-11E5-9242-09173F13E4C5
n20:hasATCCode
n21:C03AA04
n3:H-Bond-Acceptor-Count
n9:271B5682-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n9:271B5683-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n9:271B567D-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n9:271B567E-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n9:271B5680-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n9:271B567F-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n9:271B5681-363D-11E5-9242-09173F13E4C5
n3:absorption
Rapidly absorbed following oral administration.
n3:affectedOrganism
Humans and other mammals
n3:caco2-Permeability
n9:271B5690-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
58-94-6
n3:category
n3:containedIn
n17:271B566B-363D-11E5-9242-09173F13E4C5 n17:271B566C-363D-11E5-9242-09173F13E4C5 n17:271B5669-363D-11E5-9242-09173F13E4C5 n17:271B566A-363D-11E5-9242-09173F13E4C5 n17:271B5667-363D-11E5-9242-09173F13E4C5 n17:271B5668-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n9:271B5688-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n9:271B568A-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n9:271B568B-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n9:271B568D-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n9:271B5687-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n9:271B5686-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n9:271B5689-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n9:271B5677-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n9:271B5684-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n9:271B5685-363D-11E5-9242-09173F13E4C5