This HTML5 document contains 143 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/drugbank/company/
n24http://linked.opendata.cz/resource/mesh/concept/
foafhttp://xmlns.com/foaf/0.1/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/pubchem-compound/
n12http://linked.opendata.cz/resource/drugbank/dosage/
n15http://linked.opendata.cz/resource/drugbank/mixture/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/pubchem-substance/
n4http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/kegg-drug/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/drugbank/
n29http://bio2rdf.org/drugbank:
n5http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/national-drug-code-directory/
admshttp://www.w3.org/ns/adms#
n27http://www.rxlist.com/cgi/generic/
n22http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n6http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/chemspider/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n14http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n23http://linked.opendata.cz/ontology/mesh/
n7http://linked.opendata.cz/ontology/drugbank/
n26http://www.drugs.com/cdi/
n28http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/chebi/
n11http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/wikipedia/
n17http://linked.opendata.cz/resource/atc/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00868/identifier/pharmgkb/
n16http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00868
rdf:type
n7:Drug
n7:description
Benzonatate is a non-narcotic oral antitussive (cough suppressant) drug which works by anesthetizing the tissues of the lungs and pleura responsible for the cough reflex. It is chemically related to other ester anesthetics such as procaine. It has an anesthetic (numbing) action similar to that of benzocaine and "numbs" the stretch sensors in the lungs. It is the stretching of these sensors with breathing that causes the cough. It was approved by the FDA in 1958.
n7:dosage
n12:271B52D9-363D-11E5-9242-09173F13E4C5 n12:271B52DA-363D-11E5-9242-09173F13E4C5 n12:271B52DB-363D-11E5-9242-09173F13E4C5 n12:271B52DC-363D-11E5-9242-09173F13E4C5 n12:271B52D8-363D-11E5-9242-09173F13E4C5 n12:271B52D7-363D-11E5-9242-09173F13E4C5
n7:generalReferences
# Cohen V, Jellinek SP, Stansfield L, Truong H, Baseluos C, Marshall JP: Cardiac arrest with residual blindness after overdose of tessalon(R) (benzonatate) perles. J Emerg Med. 2009 Nov 4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19892505
n7:group
approved
n7:halfLife
3-8 hours
n7:indication
For the symptomatic relief of cough. Has also been applied locally in the oral cavity in adults by releasing the drug from the liquid-filled capsules to provide oropharyngeal anesthesia for conscious intubation.
n7:manufacturer
n13:271B52CF-363D-11E5-9242-09173F13E4C5 n13:271B52D0-363D-11E5-9242-09173F13E4C5 n13:271B52C9-363D-11E5-9242-09173F13E4C5 n13:271B52CA-363D-11E5-9242-09173F13E4C5 n13:271B52CD-363D-11E5-9242-09173F13E4C5 n13:271B52CE-363D-11E5-9242-09173F13E4C5 n13:271B52CB-363D-11E5-9242-09173F13E4C5 n13:271B52CC-363D-11E5-9242-09173F13E4C5
owl:sameAs
n22:DB00868 n29:DB00868
dcterms:title
Benzonatate
adms:identifier
n4:D00242 n5:0904-5904-60 n6:7413 n8:DB00868 n9:7699 n10:46506376 n18:Benzonatate n19:PA164745459 n28:3032
n7:mechanismOfAction
Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. Since these receptors are responsible for mediating the cough reflex, anesthetizing these receptors result in the inhibiton of cough production. Benzonatate also suppresses transmission of the cough reflex at the level of the medulla where the afferent impulse is transmitted to the motor nerves. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability.
n7:packager
n13:271B52AC-363D-11E5-9242-09173F13E4C5 n13:271B52AD-363D-11E5-9242-09173F13E4C5 n13:271B52AA-363D-11E5-9242-09173F13E4C5 n13:271B52AB-363D-11E5-9242-09173F13E4C5 n13:271B52A8-363D-11E5-9242-09173F13E4C5 n13:271B52A9-363D-11E5-9242-09173F13E4C5 n13:271B52A6-363D-11E5-9242-09173F13E4C5 n13:271B52A7-363D-11E5-9242-09173F13E4C5 n13:271B52B2-363D-11E5-9242-09173F13E4C5 n13:271B52B0-363D-11E5-9242-09173F13E4C5 n13:271B52B1-363D-11E5-9242-09173F13E4C5 n13:271B52AE-363D-11E5-9242-09173F13E4C5 n13:271B52AF-363D-11E5-9242-09173F13E4C5 n13:271B529B-363D-11E5-9242-09173F13E4C5 n13:271B529C-363D-11E5-9242-09173F13E4C5 n13:271B5299-363D-11E5-9242-09173F13E4C5 n13:271B529A-363D-11E5-9242-09173F13E4C5 n13:271B5297-363D-11E5-9242-09173F13E4C5 n13:271B5298-363D-11E5-9242-09173F13E4C5 n13:271B52C7-363D-11E5-9242-09173F13E4C5 n13:271B52A4-363D-11E5-9242-09173F13E4C5 n13:271B52C8-363D-11E5-9242-09173F13E4C5 n13:271B52A5-363D-11E5-9242-09173F13E4C5 n13:271B52A1-363D-11E5-9242-09173F13E4C5 n13:271B52A2-363D-11E5-9242-09173F13E4C5 n13:271B529F-363D-11E5-9242-09173F13E4C5 n13:271B52A0-363D-11E5-9242-09173F13E4C5 n13:271B529D-363D-11E5-9242-09173F13E4C5 n13:271B529E-363D-11E5-9242-09173F13E4C5 n13:271B52BD-363D-11E5-9242-09173F13E4C5 n13:271B52BE-363D-11E5-9242-09173F13E4C5 n13:271B52BB-363D-11E5-9242-09173F13E4C5 n13:271B52BC-363D-11E5-9242-09173F13E4C5 n13:271B52B9-363D-11E5-9242-09173F13E4C5 n13:271B52BA-363D-11E5-9242-09173F13E4C5 n13:271B52B8-363D-11E5-9242-09173F13E4C5 n13:271B52C5-363D-11E5-9242-09173F13E4C5 n13:271B52C6-363D-11E5-9242-09173F13E4C5 n13:271B52C3-363D-11E5-9242-09173F13E4C5 n13:271B52C4-363D-11E5-9242-09173F13E4C5 n13:271B52C1-363D-11E5-9242-09173F13E4C5 n13:271B52C2-363D-11E5-9242-09173F13E4C5 n13:271B52BF-363D-11E5-9242-09173F13E4C5 n13:271B52C0-363D-11E5-9242-09173F13E4C5 n13:271B52A3-363D-11E5-9242-09173F13E4C5 n13:271B52B3-363D-11E5-9242-09173F13E4C5 n13:271B52B4-363D-11E5-9242-09173F13E4C5 n13:271B52B7-363D-11E5-9242-09173F13E4C5 n13:271B52B5-363D-11E5-9242-09173F13E4C5 n13:271B52B6-363D-11E5-9242-09173F13E4C5 n13:271B5295-363D-11E5-9242-09173F13E4C5 n13:271B5296-363D-11E5-9242-09173F13E4C5 n13:271B5293-363D-11E5-9242-09173F13E4C5 n13:271B5294-363D-11E5-9242-09173F13E4C5 n13:271B5292-363D-11E5-9242-09173F13E4C5
n7:synonym
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl P-(butylamino)benzoate Nonaethyleneglycol monomethyl ether P-N-butylaminobenzoate Benzonatat 2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate 4-(Butylamino)benzoic acid 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester Benzononatine Benzonatatum 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosyl 4-butylaminobenzoate P-Butylaminobenzoic acid omega-O-methylnonaethyleneglycol ester Benzonatato Benzonatate
n7:toxicity
Restlessness, tremors, seizures and unconsciousness.
n7:foodInteraction
Take without regard to meals.
n7:mixture
n15:271B5291-363D-11E5-9242-09173F13E4C5
n7:synthesisReference
Matter, M.; U.S. Patent 2,714,608; August 2, 1955; assigned to Ciba Pharmaceutical Products, Inc.
n23:hasConcept
n24:M0094700
foaf:page
n26:benzonatate.html n27:benzon.htm
n7:IUPAC-Name
n11:271B52E1-363D-11E5-9242-09173F13E4C5
n7:InChI
n11:271B52E7-363D-11E5-9242-09173F13E4C5
n7:Molecular-Formula
n11:271B52E6-363D-11E5-9242-09173F13E4C5
n7:Molecular-Weight
n11:271B52E3-363D-11E5-9242-09173F13E4C5
n7:Monoisotopic-Weight
n11:271B52E4-363D-11E5-9242-09173F13E4C5
n7:SMILES
n11:271B52E5-363D-11E5-9242-09173F13E4C5
n7:Water-Solubility
n11:271B52DF-363D-11E5-9242-09173F13E4C5 n11:271B52F6-363D-11E5-9242-09173F13E4C5
n7:logP
n11:271B52DD-363D-11E5-9242-09173F13E4C5 n11:271B52F7-363D-11E5-9242-09173F13E4C5 n11:271B52E0-363D-11E5-9242-09173F13E4C5
n7:logS
n11:271B52DE-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n17:R05DB01
n7:H-Bond-Acceptor-Count
n11:271B52ED-363D-11E5-9242-09173F13E4C5
n7:H-Bond-Donor-Count
n11:271B52EE-363D-11E5-9242-09173F13E4C5
n7:InChIKey
n11:271B52E8-363D-11E5-9242-09173F13E4C5
n7:Polar-Surface-Area--PSA-
n11:271B52E9-363D-11E5-9242-09173F13E4C5
n7:Polarizability
n11:271B52EB-363D-11E5-9242-09173F13E4C5
n7:Refractivity
n11:271B52EA-363D-11E5-9242-09173F13E4C5
n7:Rotatable-Bond-Count
n11:271B52EC-363D-11E5-9242-09173F13E4C5
n7:affectedOrganism
Humans and other mammals
n7:casRegistryNumber
104-31-4
n7:category
n7:containedIn
n14:271B52D3-363D-11E5-9242-09173F13E4C5 n14:271B52D1-363D-11E5-9242-09173F13E4C5 n14:271B52D2-363D-11E5-9242-09173F13E4C5 n14:271B52D5-363D-11E5-9242-09173F13E4C5 n14:271B52D6-363D-11E5-9242-09173F13E4C5 n14:271B52D4-363D-11E5-9242-09173F13E4C5
n7:Bioavailability
n11:271B52F2-363D-11E5-9242-09173F13E4C5
n7:Ghose-Filter
n11:271B52F4-363D-11E5-9242-09173F13E4C5
n7:MDDR-Like-Rule
n11:271B52F5-363D-11E5-9242-09173F13E4C5
n7:Number-of-Rings
n11:271B52F1-363D-11E5-9242-09173F13E4C5
n7:Physiological-Charge
n11:271B52F0-363D-11E5-9242-09173F13E4C5
n7:Rule-of-Five
n11:271B52F3-363D-11E5-9242-09173F13E4C5
n7:Traditional-IUPAC-Name
n11:271B52E2-363D-11E5-9242-09173F13E4C5
n7:pKa--strongest-basic-
n11:271B52EF-363D-11E5-9242-09173F13E4C5