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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n26http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/pubchem-substance/
dctermshttp://purl.org/dc/terms/
n11http://linked.opendata.cz/resource/AHFS/
foafhttp://xmlns.com/foaf/0.1/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/drugbank/
n4http://linked.opendata.cz/resource/drugbank/company/
n19http://linked.opendata.cz/resource/drugbank/dosage/
n17http://linked.opendata.cz/resource/drugbank/mixture/
n27http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/national-drug-code-directory/
n20http://www.drugs.com/
n21http://bio2rdf.org/drugbank:
n22http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/chemspider/
admshttp://www.w3.org/ns/adms#
n24http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/chebi/
n7http://www.rxlist.com/cgi/generic/
n9http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n13http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n16http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/wikipedia/
n3http://linked.opendata.cz/ontology/drugbank/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/pharmgkb/
n5http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n25http://linked.opendata.cz/resource/drugbank/drug/DB00852/identifier/pubchem-compound/
n12http://linked.opendata.cz/resource/atc/
n10http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00852
rdf:type
n3:Drug
n3:description
An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem]
n3:dosage
n19:271B4DE8-363D-11E5-9242-09173F13E4C5 n19:271B4DE9-363D-11E5-9242-09173F13E4C5 n19:271B4DE4-363D-11E5-9242-09173F13E4C5 n19:271B4DE5-363D-11E5-9242-09173F13E4C5 n19:271B4DE6-363D-11E5-9242-09173F13E4C5 n19:271B4DE7-363D-11E5-9242-09173F13E4C5 n19:271B4DE3-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
9-16 hours
n3:indication
For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
n3:manufacturer
n4:271B4DBA-363D-11E5-9242-09173F13E4C5 n4:271B4DBB-363D-11E5-9242-09173F13E4C5
owl:sameAs
n9:DB00852 n21:DB00852
dcterms:title
Pseudoephedrine
adms:identifier
n15:PA451170 n16:Pseudoephedrine n22:6761 n23:DB00852 n24:51209 n25:7028 n26:46508190 n27:11822-0054-6
n3:mechanismOfAction
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.
n3:packager
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n3:synonym
trans-Ephedrine Pseudoephedrinum Psi-ephedrin Pseudoephedrine Psi-ephedrine (+)-threo-Ephedrine L(+)-Psi-ephedrine D-Isoephedrine Pseudoefedrina (+)-Psi-ephedrine D-Psi-ephedrine Isoephedrine L-(+)-Pseudoephedrine (+)-Pseudoephedrine D-Pseudoephedrine D-Psi-2-methylamino-1-phenyl-1-propanol (+)-(1S,2S)-Pseudoephedrine
n3:toxicity
Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
n10:hasAHFSCode
n11:12-12-12
n3:foodInteraction
Take without regard to meals.
n3:mixture
n17:271B4CCD-363D-11E5-9242-09173F13E4C5 n17:271B4CCE-363D-11E5-9242-09173F13E4C5 n17:271B4CCB-363D-11E5-9242-09173F13E4C5 n17:271B4CCC-363D-11E5-9242-09173F13E4C5 n17:271B4CD1-363D-11E5-9242-09173F13E4C5 n17:271B4CD2-363D-11E5-9242-09173F13E4C5 n17:271B4CCF-363D-11E5-9242-09173F13E4C5 n17:271B4CD0-363D-11E5-9242-09173F13E4C5 n17:271B4CD5-363D-11E5-9242-09173F13E4C5 n17:271B4CD6-363D-11E5-9242-09173F13E4C5 n17:271B4CD3-363D-11E5-9242-09173F13E4C5 n17:271B4CD4-363D-11E5-9242-09173F13E4C5 n17:271B4CD9-363D-11E5-9242-09173F13E4C5 n17:271B4CDA-363D-11E5-9242-09173F13E4C5 n17:271B4CD7-363D-11E5-9242-09173F13E4C5 n17:271B4CD8-363D-11E5-9242-09173F13E4C5 n17:271B4CDD-363D-11E5-9242-09173F13E4C5 n17:271B4CDE-363D-11E5-9242-09173F13E4C5 n17:271B4CDB-363D-11E5-9242-09173F13E4C5 n17:271B4CDC-363D-11E5-9242-09173F13E4C5 n17:271B4CE1-363D-11E5-9242-09173F13E4C5 n17:271B4CE2-363D-11E5-9242-09173F13E4C5 n17:271B4CDF-363D-11E5-9242-09173F13E4C5 n17:271B4CE0-363D-11E5-9242-09173F13E4C5 n17:271B4CE5-363D-11E5-9242-09173F13E4C5 n17:271B4CE6-363D-11E5-9242-09173F13E4C5 n17:271B4CE3-363D-11E5-9242-09173F13E4C5 n17:271B4CE4-363D-11E5-9242-09173F13E4C5 n17:271B4CE9-363D-11E5-9242-09173F13E4C5 n17:271B4CEA-363D-11E5-9242-09173F13E4C5 n17:271B4CE7-363D-11E5-9242-09173F13E4C5 n17:271B4CE8-363D-11E5-9242-09173F13E4C5 n17:271B4CF2-363D-11E5-9242-09173F13E4C5 n17:271B4CF3-363D-11E5-9242-09173F13E4C5 n17:271B4CEB-363D-11E5-9242-09173F13E4C5 n17:271B4CF1-363D-11E5-9242-09173F13E4C5 n17:271B4CF6-363D-11E5-9242-09173F13E4C5 n17:271B4CF7-363D-11E5-9242-09173F13E4C5 n17:271B4CF4-363D-11E5-9242-09173F13E4C5 n17:271B4CF5-363D-11E5-9242-09173F13E4C5 n17:271B4CFA-363D-11E5-9242-09173F13E4C5 n17:271B4CFB-363D-11E5-9242-09173F13E4C5 n17:271B4CF8-363D-11E5-9242-09173F13E4C5 n17:271B4CF9-363D-11E5-9242-09173F13E4C5 n17:271B4CFE-363D-11E5-9242-09173F13E4C5 n17:271B4CFF-363D-11E5-9242-09173F13E4C5 n17:271B4CFC-363D-11E5-9242-09173F13E4C5 n17:271B4CFD-363D-11E5-9242-09173F13E4C5 n17:271B4D02-363D-11E5-9242-09173F13E4C5 n17:271B4D03-363D-11E5-9242-09173F13E4C5 n17:271B4D00-363D-11E5-9242-09173F13E4C5 n17:271B4D01-363D-11E5-9242-09173F13E4C5 n17:271B4D06-363D-11E5-9242-09173F13E4C5 n17:271B4D07-363D-11E5-9242-09173F13E4C5 n17:271B4D04-363D-11E5-9242-09173F13E4C5 n17:271B4D05-363D-11E5-9242-09173F13E4C5 n17:271B4D0A-363D-11E5-9242-09173F13E4C5 n17:271B4D0B-363D-11E5-9242-09173F13E4C5 n17:271B4D08-363D-11E5-9242-09173F13E4C5 n17:271B4D09-363D-11E5-9242-09173F13E4C5 n17:271B4CEC-363D-11E5-9242-09173F13E4C5 n17:271B4CED-363D-11E5-9242-09173F13E4C5 n17:271B4CA8-363D-11E5-9242-09173F13E4C5 n17:271B4CF0-363D-11E5-9242-09173F13E4C5 n17:271B4D0C-363D-11E5-9242-09173F13E4C5 n17:271B4CEE-363D-11E5-9242-09173F13E4C5 n17:271B4CEF-363D-11E5-9242-09173F13E4C5 n17:271B4CA4-363D-11E5-9242-09173F13E4C5 n17:271B4CA5-363D-11E5-9242-09173F13E4C5 n17:271B4CA3-363D-11E5-9242-09173F13E4C5 n17:271B4CA9-363D-11E5-9242-09173F13E4C5 n17:271B4CAA-363D-11E5-9242-09173F13E4C5 n17:271B4CA6-363D-11E5-9242-09173F13E4C5 n17:271B4CA7-363D-11E5-9242-09173F13E4C5 n17:271B4CAD-363D-11E5-9242-09173F13E4C5 n17:271B4CAE-363D-11E5-9242-09173F13E4C5 n17:271B4CAB-363D-11E5-9242-09173F13E4C5 n17:271B4CAC-363D-11E5-9242-09173F13E4C5 n17:271B4CB1-363D-11E5-9242-09173F13E4C5 n17:271B4CB2-363D-11E5-9242-09173F13E4C5 n17:271B4CAF-363D-11E5-9242-09173F13E4C5 n17:271B4CB0-363D-11E5-9242-09173F13E4C5 n17:271B4CB5-363D-11E5-9242-09173F13E4C5 n17:271B4CB6-363D-11E5-9242-09173F13E4C5 n17:271B4CB3-363D-11E5-9242-09173F13E4C5 n17:271B4CB4-363D-11E5-9242-09173F13E4C5 n17:271B4CB9-363D-11E5-9242-09173F13E4C5 n17:271B4CBA-363D-11E5-9242-09173F13E4C5 n17:271B4CB7-363D-11E5-9242-09173F13E4C5 n17:271B4CB8-363D-11E5-9242-09173F13E4C5 n17:271B4CBD-363D-11E5-9242-09173F13E4C5 n17:271B4CBE-363D-11E5-9242-09173F13E4C5 n17:271B4CBB-363D-11E5-9242-09173F13E4C5 n17:271B4CBC-363D-11E5-9242-09173F13E4C5 n17:271B4CC1-363D-11E5-9242-09173F13E4C5 n17:271B4CC2-363D-11E5-9242-09173F13E4C5 n17:271B4CBF-363D-11E5-9242-09173F13E4C5 n17:271B4CC0-363D-11E5-9242-09173F13E4C5 n17:271B4CC5-363D-11E5-9242-09173F13E4C5 n17:271B4CC6-363D-11E5-9242-09173F13E4C5 n17:271B4CC3-363D-11E5-9242-09173F13E4C5 n17:271B4CC4-363D-11E5-9242-09173F13E4C5 n17:271B4CC9-363D-11E5-9242-09173F13E4C5 n17:271B4CCA-363D-11E5-9242-09173F13E4C5 n17:271B4CC7-363D-11E5-9242-09173F13E4C5 n17:271B4CC8-363D-11E5-9242-09173F13E4C5
n3:proteinBinding
Pseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL
n3:salt
n3:synthesisReference
Andrew G. Myers, "Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary." U.S. Patent US5760237, issued June, 1991.
foaf:page
n7:sudafed.htm n20:pseudoephedrine.html
n3:IUPAC-Name
n5:271B4DEE-363D-11E5-9242-09173F13E4C5
n3:InChI
n5:271B4DF4-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n5:271B4DF3-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B4DF0-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n5:271B4DF1-363D-11E5-9242-09173F13E4C5
n3:SMILES
n5:271B4DF2-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n5:271B4E04-363D-11E5-9242-09173F13E4C5 n5:271B4DEC-363D-11E5-9242-09173F13E4C5
n3:logP
n5:271B4E06-363D-11E5-9242-09173F13E4C5 n5:271B4DEA-363D-11E5-9242-09173F13E4C5 n5:271B4DED-363D-11E5-9242-09173F13E4C5
n3:logS
n5:271B4DEB-363D-11E5-9242-09173F13E4C5
n3:pKa
n5:271B4E07-363D-11E5-9242-09173F13E4C5
n10:hasATCCode
n12:R01BA02
n3:H-Bond-Acceptor-Count
n5:271B4DFA-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n5:271B4DFB-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n5:271B4DF5-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n5:271B4DF6-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n5:271B4DF8-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n5:271B4DF7-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n5:271B4DF9-363D-11E5-9242-09173F13E4C5
n3:absorption
Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
90-82-4
n3:containedIn
n13:271B4DC9-363D-11E5-9242-09173F13E4C5 n13:271B4DD4-363D-11E5-9242-09173F13E4C5 n13:271B4DC7-363D-11E5-9242-09173F13E4C5 n13:271B4DC8-363D-11E5-9242-09173F13E4C5 n13:271B4DC5-363D-11E5-9242-09173F13E4C5 n13:271B4DC6-363D-11E5-9242-09173F13E4C5 n13:271B4DC3-363D-11E5-9242-09173F13E4C5 n13:271B4DC4-363D-11E5-9242-09173F13E4C5 n13:271B4DC1-363D-11E5-9242-09173F13E4C5 n13:271B4DC2-363D-11E5-9242-09173F13E4C5 n13:271B4DBF-363D-11E5-9242-09173F13E4C5 n13:271B4DC0-363D-11E5-9242-09173F13E4C5 n13:271B4DBD-363D-11E5-9242-09173F13E4C5 n13:271B4DBE-363D-11E5-9242-09173F13E4C5 n13:271B4DBC-363D-11E5-9242-09173F13E4C5 n13:271B4DE1-363D-11E5-9242-09173F13E4C5 n13:271B4DE2-363D-11E5-9242-09173F13E4C5 n13:271B4DDF-363D-11E5-9242-09173F13E4C5 n13:271B4DE0-363D-11E5-9242-09173F13E4C5 n13:271B4DDD-363D-11E5-9242-09173F13E4C5 n13:271B4DDE-363D-11E5-9242-09173F13E4C5 n13:271B4DDB-363D-11E5-9242-09173F13E4C5 n13:271B4DDC-363D-11E5-9242-09173F13E4C5 n13:271B4DD9-363D-11E5-9242-09173F13E4C5 n13:271B4DDA-363D-11E5-9242-09173F13E4C5 n13:271B4DD7-363D-11E5-9242-09173F13E4C5 n13:271B4DD8-363D-11E5-9242-09173F13E4C5 n13:271B4DD5-363D-11E5-9242-09173F13E4C5 n13:271B4DD6-363D-11E5-9242-09173F13E4C5 n13:271B4DCA-363D-11E5-9242-09173F13E4C5 n13:271B4DCB-363D-11E5-9242-09173F13E4C5 n13:271B4DD2-363D-11E5-9242-09173F13E4C5 n13:271B4DD3-363D-11E5-9242-09173F13E4C5 n13:271B4DD0-363D-11E5-9242-09173F13E4C5 n13:271B4DD1-363D-11E5-9242-09173F13E4C5 n13:271B4DCE-363D-11E5-9242-09173F13E4C5 n13:271B4DCF-363D-11E5-9242-09173F13E4C5 n13:271B4DCC-363D-11E5-9242-09173F13E4C5 n13:271B4DCD-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n5:271B4E00-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n5:271B4E02-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n5:271B4E03-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n5:271B4E05-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n5:271B4DFF-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n5:271B4DFE-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n5:271B4E01-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n5:271B4DEF-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n5:271B4DFC-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n5:271B4DFD-363D-11E5-9242-09173F13E4C5