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Statements

Subject Item
n2:DB00840
rdf:type
n3:Drug
n3:description
Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer.
n3:dosage
n8:271B4A6A-363D-11E5-9242-09173F13E4C5 n8:271B4A6B-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Wander AH: Long-term use of hydroxypropyl cellulose ophthalmic insert to relieve symptoms of dry eye in a contact lens wearer: case-based experience. Eye Contact Lens. 2011 Jan;37(1):39-44. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/21178699 # McDonald M, D'Aversa G, Perry HD, Wittpenn JR, Nelinson DS: Correlating patient-reported response to hydroxypropyl cellulose ophthalmic insert (LACRISERT(R)) therapy with clinical outcomes: tools for predicting response. Curr Eye Res. 2010 Oct;35(10):880-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20858108 # Luchs JI, Nelinson DS, Macy JI: Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. Cornea. 2010 Dec;29(12):1417-27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20847657
n3:group
approved
n3:indication
Used to relieve dryness and irritation caused by reduced tear flow that occurs in certain eye diseases (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes.
n3:manufacturer
n14:271B4A66-363D-11E5-9242-09173F13E4C5
owl:sameAs
n16:DB00840 n17:DB00840
dcterms:title
Hydroxypropyl cellulose
adms:identifier
n10:PA164746492 n11:Hydroxypropyl_cellulose n18:DB00840 n19:D01536 n22:0006-3380-60
n3:mechanismOfAction
Hydroxypropyl cellulose is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. Hydroxypropyl cellulose possesses good surface activity but does not gel as it forms open helical coils. In general Hydroxypropyl cellulose is a water-soluble thickener, emulsifier and film-former often used in tablet coating.
n3:packager
n14:271B4A63-363D-11E5-9242-09173F13E4C5 n14:271B4A64-363D-11E5-9242-09173F13E4C5 n14:271B4A65-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
Studies conducted in rats fed 14C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.
n3:synonym
Hypromellose phthtalate Hyprolose Hydroxypropyl cellulose Hydroxypropylcellulose Hiprolosa Hyprolosum Hydroxypropylmethylcellulose phthalate
n3:toxicity
LD<sub>50</sub>=10200 mg/kg (oral, rat)
n3:mixture
n4:271B4A62-363D-11E5-9242-09173F13E4C5
n3:proteinBinding
None
n3:synthesisReference
Seiji Orii, Yukio Sasagawa, Akinori Ito, Maruyama, Hiromi, Yoshiteru Sakai, "Process of producing hydroxypropyl cellulose." U.S. Patent US4292426, issued April, 1964.
n20:hasConcept
n21:M0051638
foaf:page
n6:artificial-tear-insert.html n13:lacrisert.htm
n3:absorption
Studies conducted in rats fed 14 C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9004-64-2
n3:category
n3:containedIn
n7:271B4A67-363D-11E5-9242-09173F13E4C5 n7:271B4A68-363D-11E5-9242-09173F13E4C5 n7:271B4A69-363D-11E5-9242-09173F13E4C5