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Namespace Prefixes

PrefixIRI
n10http://linked.opendata.cz/resource/drugbank/drug/DB00805/identifier/chebi/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/mesh/concept/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00805/identifier/pharmgkb/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00805/identifier/pubchem-compound/
n7http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n14http://linked.opendata.cz/resource/drugbank/drug/DB00805/identifier/pubchem-substance/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00805/identifier/drugbank/
n15http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
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owlhttp://www.w3.org/2002/07/owl#
n12http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
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n11http://linked.opendata.cz/resource/drugbank/drug/DB00805/identifier/chemspider/
n17http://linked.opendata.cz/resource/atc/
n16http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00805
rdf:type
n3:Drug
n3:description
Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
n3:group
approved
n3:indication
For the treatment of depression
owl:sameAs
n7:DB00805 n15:DB00805
dcterms:title
Minaprine
adms:identifier
n9:PA164748351 n10:51038 n11:4054 n14:46505380 n18:DB00805 n19:4199
n3:mechanismOfAction
Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of MAO-A (RIMA).It has also been found to inhibit acetylcholinesterase.
n3:synonym
4-Methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin Minaprinum Minaprina N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine
n3:salt
n12:hasConcept
n13:M0048328
n3:IUPAC-Name
n4:271B3FA7-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B3FAD-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B3FAC-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3FA9-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B3FAA-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B3FAB-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B3FBD-363D-11E5-9242-09173F13E4C5 n4:271B3FA5-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B3FBF-363D-11E5-9242-09173F13E4C5 n4:271B3FA3-363D-11E5-9242-09173F13E4C5 n4:271B3FA6-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B3FA4-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n17:N06AX07
n3:H-Bond-Acceptor-Count
n4:271B3FB3-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B3FB4-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B3FAE-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B3FAF-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B3FB1-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B3FB0-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B3FB2-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
25905-77-5
n3:category
n3:Bioavailability
n4:271B3FB9-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B3FBB-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B3FBC-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B3FBE-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B3FB8-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B3FB7-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B3FBA-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B3FA8-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B3FB5-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B3FB6-363D-11E5-9242-09173F13E4C5