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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n16http://linked.opendata.cz/resource/drugbank/company/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/chemspider/
n17http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n14http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/wikipedia/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/pharmgkb/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n7http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/kegg-compound/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/pubchem-compound/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n11http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/kegg-drug/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/pubchem-substance/
n6http://linked.opendata.cz/resource/drugbank/drug/DB00791/identifier/drugbank/

Statements

Subject Item
n2:DB00791
rdf:type
n3:Drug
n3:description
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. [PubChem]
n3:group
approved
n3:indication
Used for its antineoplastic properties.
n3:manufacturer
n16:271B6383-363D-11E5-9242-09173F13E4C5
owl:sameAs
n14:DB00791 n17:DB00791
dcterms:title
Uracil mustard
adms:identifier
n6:DB00791 n7:C11686 n8:5959 n9:6194 n10:46506168 n11:D06265 n12:PA451830 n15:Uracil_mustard
n3:mechanismOfAction
After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
n3:synonym
Uracil mustard 5-[Di(beta-chloroethyl)amino]uracil Aminouracil mustard 5-(Di-2-chloroethyl)aminouracil 5-Aminouracil mustard Uracil nitrogen mustard 5-N,N-Bis(2-chloroethyl)aminouracil 5-[Bis(2-chloroethyl)amino]-2,4(1H,3H)-pyrimidinedione
n3:proteinBinding
5%
n3:IUPAC-Name
n4:271B6388-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B638E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B638D-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B638A-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B638B-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B638C-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B639E-363D-11E5-9242-09173F13E4C5 n4:271B6386-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B63A0-363D-11E5-9242-09173F13E4C5 n4:271B6387-363D-11E5-9242-09173F13E4C5 n4:271B6384-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B6385-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B6394-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B6395-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B638F-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B6390-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B6392-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B6391-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B6393-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
66-75-1
n3:Bioavailability
n4:271B639A-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B639C-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B639D-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B639F-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B6399-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B6398-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B639B-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B6389-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B6396-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B6397-363D-11E5-9242-09173F13E4C5