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Namespace Prefixes

PrefixIRI
n17http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/wikipedia/
n22http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n25http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/pharmgkb/
n12http://linked.opendata.cz/resource/AHFS/
n13http://linked.opendata.cz/resource/drugbank/company/
foafhttp://xmlns.com/foaf/0.1/
n27http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/kegg-compound/
n28http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/pdb/
n10http://linked.opendata.cz/resource/mesh/concept/
n20http://linked.opendata.cz/resource/drugbank/dosage/
n26http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/pubchem-compound/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/pubchem-substance/
n15http://bio2rdf.org/drugbank:
n4http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/drugbank/
admshttp://www.w3.org/ns/adms#
n19http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n16http://linked.opendata.cz/resource/drugbank/medicinal-product/
n9http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n5http://linked.opendata.cz/ontology/drugbank/
n24http://www.drugs.com/cdi/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/chemspider/
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n7http://linked.opendata.cz/resource/drugbank/drug/DB00738/identifier/chebi/
n11http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00738
rdf:type
n5:Drug
n5:description
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. [PubChem]
n5:dosage
n20:271B5335-363D-11E5-9242-09173F13E4C5 n20:271B5336-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Nguewa PA, Fuertes MA, Cepeda V, Iborra S, Carrion J, Valladares B, Alonso C, Perez JM: Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers. 2005 Oct;2(10):1387-400. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17191940
n5:group
approved
n5:halfLife
9.1-13.2 hours
n5:indication
For the treatment of pneumonia due to <i>Pneumocystis carinii</i>.
n5:manufacturer
n13:271B5330-363D-11E5-9242-09173F13E4C5 n13:271B5331-363D-11E5-9242-09173F13E4C5 n13:271B532E-363D-11E5-9242-09173F13E4C5 n13:271B532F-363D-11E5-9242-09173F13E4C5 n13:271B532D-363D-11E5-9242-09173F13E4C5
owl:sameAs
n15:DB00738 n19:DB00738
dcterms:title
Pentamidine
adms:identifier
n4:DB00738 n7:45081 n8:4573 n17:Pentamidine n23:46508562 n25:PA450850 n26:4735 n27:C07420 n28:PNT
n5:mechanismOfAction
The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
n5:packager
n13:271B532C-363D-11E5-9242-09173F13E4C5 n13:271B532A-363D-11E5-9242-09173F13E4C5 n13:271B532B-363D-11E5-9242-09173F13E4C5 n13:271B5328-363D-11E5-9242-09173F13E4C5 n13:271B5329-363D-11E5-9242-09173F13E4C5
n5:synonym
Pentamidindiisetionat P,P'-(pentamethylenedioxy)dibenzamidine Pentamidinum 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide Pentamidine 4,4'-Diamidinodiphenoxypentane Pentamidina 4,4'-(Pentamethylenedioxy)dibenzamidine 1,5-Bis(4-amidinophenoxy)pentane Pentamidin
n5:toxicity
Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea.
n11:hasAHFSCode
n12:08-30-92
n5:proteinBinding
69%
n5:salt
n9:hasConcept
n10:M0016169
foaf:page
n22:pentam.htm n24:pentamidine.html
n5:IUPAC-Name
n6:271B533B-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B5341-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B5340-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B533D-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B533E-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B533F-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B5339-363D-11E5-9242-09173F13E4C5 n6:271B5350-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B5337-363D-11E5-9242-09173F13E4C5 n6:271B533A-363D-11E5-9242-09173F13E4C5 n6:271B5352-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B5338-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Acceptor-Count
n6:271B5347-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B5348-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B5342-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B5343-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B5345-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B5344-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B5346-363D-11E5-9242-09173F13E4C5
n5:absorption
Absorbed poorly through the gastrointestinal tract and is usually administered parenterally.
n5:affectedOrganism
Pneumocystis carinii
n5:casRegistryNumber
100-33-4
n5:category
n5:containedIn
n16:271B5333-363D-11E5-9242-09173F13E4C5 n16:271B5334-363D-11E5-9242-09173F13E4C5 n16:271B5332-363D-11E5-9242-09173F13E4C5
n5:Bioavailability
n6:271B534C-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B534E-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B534F-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n6:271B5351-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B534B-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B534A-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B534D-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B533C-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B5349-363D-11E5-9242-09173F13E4C5