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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
foafhttp://xmlns.com/foaf/0.1/
n8http://linked.opendata.cz/resource/drugbank/company/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00725/identifier/kegg-drug/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00725/identifier/drugbank/
n17http://linked.opendata.cz/resource/drugbank/mixture/
n16http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n12http://linked.opendata.cz/resource/drugbank/drug/DB00725/identifier/chebi/
n6http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n15http://www.drugs.com/cdi/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00725/identifier/wikipedia/
n7http://linked.opendata.cz/resource/drugbank/property/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00725/identifier/pharmgkb/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB00725
rdf:type
n3:Drug
n3:description
Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.
n3:group
approved
n3:indication
Used in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcers, gastric ulcers and duodenal ulcers, to reduce further gastric acid secretion and delay gastric emptying.
owl:sameAs
n6:DB00725 n16:DB00725
dcterms:title
Homatropine Methylbromide
adms:identifier
n11:D02070 n12:50373 n13:DB00725 n18:Homatropine_Methylbromide n19:PA164749405
n3:mechanismOfAction
Homatropine is a quaternary ammonium muscarinic acetylcholine receptor antagonist. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Homatropine methylbromide inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder.
n3:packager
n8:271B4F1D-363D-11E5-9242-09173F13E4C5 n8:271B4F1E-363D-11E5-9242-09173F13E4C5 n8:271B4F1B-363D-11E5-9242-09173F13E4C5 n8:271B4F1C-363D-11E5-9242-09173F13E4C5 n8:271B4F18-363D-11E5-9242-09173F13E4C5 n8:271B4F19-363D-11E5-9242-09173F13E4C5 n8:271B4F17-363D-11E5-9242-09173F13E4C5 n8:271B4F15-363D-11E5-9242-09173F13E4C5 n8:271B4F16-363D-11E5-9242-09173F13E4C5 n8:271B4F10-363D-11E5-9242-09173F13E4C5 n8:271B4F11-363D-11E5-9242-09173F13E4C5 n8:271B4F0F-363D-11E5-9242-09173F13E4C5 n8:271B4F14-363D-11E5-9242-09173F13E4C5 n8:271B4F12-363D-11E5-9242-09173F13E4C5 n8:271B4F13-363D-11E5-9242-09173F13E4C5 n8:271B4F1A-363D-11E5-9242-09173F13E4C5
n3:synonym
Homatropini methylbromidum 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide mandelate Methylhomatropinum bromatum Metilbromuro de homatropina Tropinium methobromide mandelate 8-Methylhomatropinium bromide Omatropina metilbromuro Homatropine methylbromide Methylhomatropine bromide Methylbromure d'homatropine Methylhomatropine
n3:mixture
n17:271B4F0D-363D-11E5-9242-09173F13E4C5 n17:271B4F0E-363D-11E5-9242-09173F13E4C5 n17:271B4F0B-363D-11E5-9242-09173F13E4C5 n17:271B4F0C-363D-11E5-9242-09173F13E4C5 n17:271B4F09-363D-11E5-9242-09173F13E4C5 n17:271B4F0A-363D-11E5-9242-09173F13E4C5
foaf:page
n15:homatropine-drops.html
n3:IUPAC-Name
n7:271B4F29-363D-11E5-9242-09173F13E4C5
n3:InChI
n7:271B4F2F-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n7:271B4F2E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n7:271B4F2B-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n7:271B4F2C-363D-11E5-9242-09173F13E4C5
n3:SMILES
n7:271B4F2D-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n7:271B4F27-363D-11E5-9242-09173F13E4C5
n3:logP
n7:271B4F25-363D-11E5-9242-09173F13E4C5 n7:271B4F28-363D-11E5-9242-09173F13E4C5 n7:271B4F40-363D-11E5-9242-09173F13E4C5
n3:logS
n7:271B4F26-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n7:271B4F35-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n7:271B4F36-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n7:271B4F30-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n7:271B4F31-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n7:271B4F33-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n7:271B4F32-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n7:271B4F34-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
80-49-9
n3:category
n3:containedIn
n4:271B4F23-363D-11E5-9242-09173F13E4C5 n4:271B4F24-363D-11E5-9242-09173F13E4C5 n4:271B4F21-363D-11E5-9242-09173F13E4C5 n4:271B4F22-363D-11E5-9242-09173F13E4C5 n4:271B4F1F-363D-11E5-9242-09173F13E4C5 n4:271B4F20-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n7:271B4F3B-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n7:271B4F3D-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n7:271B4F3E-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n7:271B4F3F-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n7:271B4F3A-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n7:271B4F39-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n7:271B4F3C-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n7:271B4F2A-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n7:271B4F37-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n7:271B4F38-363D-11E5-9242-09173F13E4C5