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Namespace Prefixes

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Statements

Subject Item
n2:DB00667
rdf:type
n3:Drug
n3:description
Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.
n3:dosage
n23:271B3EE2-363D-11E5-9242-09173F13E4C5 n23:271B3EE3-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
n3:manufacturer
n20:271B3EDE-363D-11E5-9242-09173F13E4C5
owl:sameAs
n8:DB00667 n21:DB00667
dcterms:title
Histamine Phosphate
adms:identifier
n10:0268-0248-05 n12:PA449880 n13:DB00667 n14:65513 n15:46509118 n19:58959
n3:mechanismOfAction
Histamine acts directly on the blood vessels to dilate arteries and capillaries; this action is mediated by both H 1- and H 2-receptors. Capillary dilatation may produce flushing of the face, a decrease in systemic blood pressure, and gastric gland secretion, causing an increased secretion of gastric juice of high acidity. Increased capillary permeability accompanies capillary dilatation, producing an outward passage of plasma protein and fluid into the extracellular spaces, an increase in lymph flow and protein content, and the formation of edema. In addition, histamine has a direct stimulant action on smooth muscle, producing contraction if H 1-receptors are activated, or mostly relaxation if H 2-receptors are activated. Also in humans, the stimulant effect of histamine may cause contraction of the intestinal muscle. However, little effect is noticed on the uterus, bladder, or gallbladder. Histamine has some stimulant effect on duodenal, salivary, pancreatic, bronchial, and lacrimal glands. Histamine also can bind to H3 and H4 receptors which are involved in the CNS/PNS neurotransmitter release and immune system chemotaxis, respectively.
n3:packager
n20:271B3EDC-363D-11E5-9242-09173F13E4C5 n20:271B3EDD-363D-11E5-9242-09173F13E4C5 n20:271B3EDA-363D-11E5-9242-09173F13E4C5 n20:271B3EDB-363D-11E5-9242-09173F13E4C5
n3:synonym
4-(2-Aminoethyl)imidazole di-acid phosphate Histaminum Histamine dihydrogen phosphate Histamine acid phosphate Histamine diphosphate Histamine phosphate (1:2) Histamine biphosphate 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
n3:toxicity
LD<sub>50</sub>=807 mg/kg (mouse, oral). Side effects can lead to hypertension, hypotension, headache, dizziness, nervousness and tachycardia. Large overdoses can lead to seizures.
n5:hasAHFSCode
n11:36-89-00%2A n11:36-36-00
foaf:page
n18:histamine-phosphate-intradermal.html
n3:IUPAC-Name
n4:271B3EE5-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B3EEB-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B3EEA-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3EE7-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B3EE8-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B3EE9-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B3EE4-363D-11E5-9242-09173F13E4C5 n4:271B3EFC-363D-11E5-9242-09173F13E4C5
n5:hasATCCode
n6:V04CG03
n3:H-Bond-Acceptor-Count
n4:271B3EF1-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B3EF2-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B3EEC-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B3EED-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B3EEF-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B3EEE-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B3EF0-363D-11E5-9242-09173F13E4C5
n3:absorption
Readily absorbed after parenteral administration
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
51-74-1
n3:category
n3:containedIn
n16:271B3EE1-363D-11E5-9242-09173F13E4C5 n16:271B3EDF-363D-11E5-9242-09173F13E4C5 n16:271B3EE0-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B3EF7-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B3EF9-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B3EFA-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B3EFB-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B3EF6-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B3EF5-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B3EF8-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B3EE6-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B3EF3-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B3EF4-363D-11E5-9242-09173F13E4C5