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Namespace Prefixes

PrefixIRI
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n25http://linked.opendata.cz/resource/drugbank/drug/DB00645/identifier/wikipedia/
n11http://bio2rdf.org/drugbank:
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n20http://linked.opendata.cz/resource/drugbank/drug/DB00645/identifier/kegg-compound/
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n5http://linked.opendata.cz/resource/atc/
n4http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00645
rdf:type
n3:Drug
n3:description
Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray.
n3:group
approved
n3:halfLife
Approximately 30 to 60 minutes.
n3:indication
Used to provide topical anesthesia of accessible mucous membranes prior to examination, endoscopy or instrumentation, or other procedures involving the esophagus, larynx, mouth, pharynx or throat, respiratory tract or trachea, urinary tract, or vagina. Also used to suppress the gag reflex and/or other laryngeal and esophageal reflexes to facilitate dental examination or procedures (including oral surgery), endoscopy, or intubation. Also used for relief of canker sores, cold sores or fever blister.
n3:manufacturer
n14:271B5FAA-363D-11E5-9242-09173F13E4C5
owl:sameAs
n9:DB00645 n11:DB00645
dcterms:title
Dyclonine
adms:identifier
n16:3068 n17:DB00645 n18:4724 n19:3180 n20:C07881 n21:46506697 n23:PA164748037 n25:Dyclonine
n3:mechanismOfAction
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
n3:packager
n14:271B5FA9-363D-11E5-9242-09173F13E4C5 n14:271B5FA8-363D-11E5-9242-09173F13E4C5
n3:synonym
Diclonina Dyclonin Dyclonine Dycloninum Dyclocaine 4'-Butoxy-3-piperidinopropiophenone 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone 4-Butoxy-beta-piperidinopropiophenone 4-N-Butoxy-beta-(1-piperidyl)propiophenone 3-Piperidino-4'-butoxypropiophenone 2-(1-Piperidyl)ethyl P-butoxyphenyl ketone
n3:toxicity
Symptoms of overdose include cardiovascular system depression, CNS toxicity, and methemoglobinemia.
n4:hasAHFSCode
n24:52-16-00
n3:mixture
n13:271B5FA6-363D-11E5-9242-09173F13E4C5 n13:271B5FA7-363D-11E5-9242-09173F13E4C5
n3:salt
n3:synthesisReference
Tianjiang Sun, Xiaohong Gu, Hongguo Lu, Min Chen, "Oral Preparation of Dyclonine Hydrochloride." U.S. Patent US20080200506, issued August 21, 2008.
foaf:page
n7:dyclonine-lozenges.html
n3:IUPAC-Name
n10:271B5FB0-363D-11E5-9242-09173F13E4C5
n3:InChI
n10:271B5FB6-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n10:271B5FB5-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n10:271B5FB2-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n10:271B5FB3-363D-11E5-9242-09173F13E4C5
n3:SMILES
n10:271B5FB4-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n10:271B5FAE-363D-11E5-9242-09173F13E4C5 n10:271B5FC6-363D-11E5-9242-09173F13E4C5
n3:logP
n10:271B5FAC-363D-11E5-9242-09173F13E4C5 n10:271B5FAF-363D-11E5-9242-09173F13E4C5 n10:271B5FC8-363D-11E5-9242-09173F13E4C5
n3:logS
n10:271B5FAD-363D-11E5-9242-09173F13E4C5
n4:hasATCCode
n5:R02AD04 n5:N01BX02
n3:H-Bond-Acceptor-Count
n10:271B5FBC-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n10:271B5FBD-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n10:271B5FB7-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n10:271B5FB8-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n10:271B5FBA-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n10:271B5FB9-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n10:271B5FBB-363D-11E5-9242-09173F13E4C5
n3:absorption
Readily absorbed through mucous membranes into the systemic circulation. The rate of absorption is influenced by the vascularity or rate of blood flow at the site of application, the total dosage (concentration and volume) administered, and the duration of exposure. Absorption from mucous membranes of the throat or respiratory tract may be especially rapid.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
586-60-7
n3:category
n3:containedIn
n22:271B5FAB-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n10:271B5FC2-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n10:271B5FC4-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n10:271B5FC5-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n10:271B5FC7-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n10:271B5FC1-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n10:271B5FC0-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n10:271B5FC3-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n10:271B5FB1-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n10:271B5FBE-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n10:271B5FBF-363D-11E5-9242-09173F13E4C5