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Namespace Prefixes

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Statements

Subject Item
n2:DB00644
rdf:type
n5:Drug
n5:description
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
n5:generalReferences
# Dungan HM, Clifton DK, Steiner RA: Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2006 Mar;147(3):1154-8. Epub 2005 Dec 22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16373418 # Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A: Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett. 2006 Jul 3;401(3):225-30. Epub 2006 Apr 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16621281
n5:group
approved
n5:halfLife
Very short, initial, 2 to 10 minutes; terminal, 10 to 40 minutes
n5:indication
For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
n5:manufacturer
n9:271B5F88-363D-11E5-9242-09173F13E4C5 n9:271B5F89-363D-11E5-9242-09173F13E4C5
owl:sameAs
n20:DB00644 n22:DB00644
dcterms:title
Gonadorelin
adms:identifier
n7:DB00644 n11:33562 n12:36523 n13:46506144 n14:C07607 n15:PA449801 n16:Gonadorelin
n5:mechanismOfAction
Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.
n5:packager
n9:271B5F87-363D-11E5-9242-09173F13E4C5 n9:271B5F86-363D-11E5-9242-09173F13E4C5
n5:synonym
Gonadorelin Gonadorelina Fertagyl Gonadoliberin I GnRH GnRH-I Gonadorelinum Luteinizing Hormone-releasing Factor Diacetate Tetrahydrate Gonadoréline
n5:toxicity
LD<sub>50</sub>>3000 mg/kg (rat, oral)
n3:hasAHFSCode
n4:68-18-00
n5:salt
n5:synthesisReference
Rainer Uhmann, Kurt Radscheit, "Process for the low-racemization preparation of peptide intermediates of the synthesis of gonadorelin and gonadorelin analogs, and new intermediates for this process." U.S. Patent US4691008, issued December, 1984.
foaf:page
n18:gonadorelin.html n21:gonadorelin.htm
n5:IUPAC-Name
n10:271B5F8E-363D-11E5-9242-09173F13E4C5
n5:InChI
n10:271B5F94-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n10:271B5F93-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n10:271B5F90-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n10:271B5F91-363D-11E5-9242-09173F13E4C5
n5:SMILES
n10:271B5F92-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n10:271B5F8C-363D-11E5-9242-09173F13E4C5 n10:271B5FA4-363D-11E5-9242-09173F13E4C5
n5:logP
n10:271B5F8D-363D-11E5-9242-09173F13E4C5 n10:271B5F8A-363D-11E5-9242-09173F13E4C5 n10:271B5FA5-363D-11E5-9242-09173F13E4C5
n5:logS
n10:271B5F8B-363D-11E5-9242-09173F13E4C5
n3:hasATCCode
n8:H01CA01 n8:V04CM01
n5:H-Bond-Acceptor-Count
n10:271B5F9A-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n10:271B5F9B-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n10:271B5F95-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n10:271B5F96-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n10:271B5F98-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n10:271B5F97-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n10:271B5F99-363D-11E5-9242-09173F13E4C5
n5:absorption
Rapidly absorbed when injected
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
6918-09-8
n5:Bioavailability
n10:271B5FA0-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n10:271B5FA2-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n10:271B5FA3-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n10:271B5F9F-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n10:271B5F9E-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n10:271B5FA1-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n10:271B5F8F-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n10:271B5F9C-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n10:271B5F9D-363D-11E5-9242-09173F13E4C5