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Namespace Prefixes

PrefixIRI
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n19http://linked.opendata.cz/resource/drugbank/drug/DB00638/identifier/kegg-compound/
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owlhttp://www.w3.org/2002/07/owl#
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n21http://linked.opendata.cz/resource/drugbank/drug/DB00638/identifier/chemspider/
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n17http://linked.opendata.cz/resource/drugbank/drug/DB00638/identifier/chebi/

Statements

Subject Item
n2:DB00638
rdf:type
n3:Drug
n3:description
A starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function. [PubChem]
n3:generalReferences
# Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ: A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr. 2005 Aug;82(2):471-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16087995 # Coudray C, Demigne C, Rayssiguier Y: Effects of dietary fibers on magnesium absorption in animals and humans. J Nutr. 2003 Jan;133(1):1-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12514257 # Coussement PA: Inulin and oligofructose: safe intakes and legal status. J Nutr. 1999 Jul;129(7 Suppl):1412S-7S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10395609 # Roberfroid MB: Introducing inulin-type fructans. Br J Nutr. 2005 Apr;93 Suppl 1:S13-25. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15877886
n3:group
nutraceutical approved
n3:halfLife
2-4 hours
n3:indication
Historically used in an important medical test of renal function, specifically a measure of glomerular filtration rate. Sometimes used to help relieve symptoms of diabetes mellitus - a condition characterised by hyperglycemia and/or hyperinsulinemia.
n3:manufacturer
n5:271B5DEF-363D-11E5-9242-09173F13E4C5
owl:sameAs
n12:DB00638 n16:DB00638
dcterms:title
Inulin
adms:identifier
n7:Inulin n13:46508287 n14:PA450043 n15:24763 n17:15443 n19:C03323 n20:D00171 n21:23149 n22:DB00638
n3:mechanismOfAction
As a diagnostic agent, inulin is readily soluble and essentially indigestible. It readily passes through the blood and into the urine. It is neither secreted nor resorbed by the kidney making it an excellent indicator for renal clearance rates. The inulin clearance test has largely been succeeded by the creatinine clearance test as a measure of glomerular filtration rate. As a hypoglycemic agent, inulin is not digestible by human enzymes ptyalin and amylase, which are designed to digest starch. As a result, inulin passes through much of the digestive system intact. It is only in the colon that bacteria metabolise inulin, with the release of significant quantities of carbon dioxide and/or methane. Because inulin is not broken down into simple sugars (monosaccharides) by normal digestion, it does not elevate blood sugar levels, hence, helping diabetics regulate blood sugar levels.
n3:packager
n5:271B5DED-363D-11E5-9242-09173F13E4C5 n5:271B5DEE-363D-11E5-9242-09173F13E4C5
n3:proteinBinding
None
n3:synthesisReference
Ernst Hoehn, Curtis J. McKay, E. Donald Murray, "Production of high fructose syrup from inulin involving ultrafiltration." U.S. Patent US4421852, issued July, 1981.
foaf:page
n9:inu_0299.shtml n18:inulin-intravenous.html
n3:IUPAC-Name
n4:271B5DF1-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5DF7-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5DF6-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5DF3-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5DF4-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5DF5-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5E06-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5DF0-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B5DFC-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5DFD-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5DF8-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5DF9-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5DFA-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5DFB-363D-11E5-9242-09173F13E4C5
n3:absorption
Poorly absorbed, passes through to urine unmetabolized
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9005-80-5
n3:category
n3:Bioavailability
n4:271B5E02-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5E04-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B5E05-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B5E07-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5E01-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5E00-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5E03-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5DF2-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5DFE-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5DFF-363D-11E5-9242-09173F13E4C5