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Namespace Prefixes

PrefixIRI
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n16http://linked.opendata.cz/resource/drugbank/dosage/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00615/identifier/chebi/
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n13http://linked.opendata.cz/resource/atc/
n12http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00615
rdf:type
n3:Drug
n3:description
A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]
n3:dosage
n16:271B56C5-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
45 (± 17) hours
n3:indication
For the prevention of disseminated <i>Mycobacterium avium</i> complex (MAC) disease in patients with advanced HIV infection.
n3:manufacturer
n9:271B56C3-363D-11E5-9242-09173F13E4C5
owl:sameAs
n6:DB00615 n30:DB00615
dcterms:title
Rifabutin
adms:identifier
n18:8857 n19:6323490 n20:46506468 n21:C07235 n23:4883445 n24:DB00615 n25:RBT n26:PA451249 n27:D00424 n28:0013-5301-17 n31:Rifabutin
n3:mechanismOfAction
Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death.
n3:packager
n9:271B56C1-363D-11E5-9242-09173F13E4C5 n9:271B56C2-363D-11E5-9242-09173F13E4C5 n9:271B56BF-363D-11E5-9242-09173F13E4C5 n9:271B56C0-363D-11E5-9242-09173F13E4C5 n9:271B56BE-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
A mass-balance study in three healthy adult volunteers with 14C-labeled rifabutin showed that 53% of the oral dose was excreted in the urine, primarily as metabolites. About 30% of the dose is excreted in the feces.
n3:synonym
Rifabutinum Rifabutina Mycobutin (tn) Ansamicin 4-N-Isobutylspiropiperidylrifamycin S Rifabutine 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv Rifabutin Ansamycin
n3:toxicity
LD<sub>50</sub> = 4.8 g/kg (mouse, male)
n12:hasAHFSCode
n29:08-16-04
n3:foodInteraction
Take with food to reduce irritation. High-fat meals slow the rate of absorption.
n3:proteinBinding
85%
n14:hasConcept
n15:M0026934
foaf:page
n11:rifabutin.htm n22:rifabutin.html
n3:IUPAC-Name
n4:271B56CA-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B56D0-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B56CF-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B56CC-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B56CD-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B56CE-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B56C8-363D-11E5-9242-09173F13E4C5 n4:271B56E0-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B56E1-363D-11E5-9242-09173F13E4C5 n4:271B56C6-363D-11E5-9242-09173F13E4C5 n4:271B56C9-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B56C7-363D-11E5-9242-09173F13E4C5
n12:hasATCCode
n13:J04AB04
n3:H-Bond-Acceptor-Count
n4:271B56D6-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B56D7-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B56D1-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B56D2-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B56D4-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B56D3-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B56D5-363D-11E5-9242-09173F13E4C5
n3:absorption
Rifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%.
n3:affectedOrganism
Mycobacterium leprae Mycobacterium avium Mycobacterium tuberculosis Enteric bacteria and other eubacteria
n3:casRegistryNumber
72559-06-9
n3:category
n3:clearance
* 0.69 +/- 0.32 L/hr/kg
n3:containedIn
n8:271B56C4-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B56DC-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B56DE-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B56DF-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B56DB-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B56DA-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B56DD-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B56CB-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B56D8-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B56D9-363D-11E5-9242-09173F13E4C5