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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/pubchem-compound/
dctermshttp://purl.org/dc/terms/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/kegg-drug/
n17http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/pubchem-substance/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/drugbank/
n14http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/iuphar/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/guide-to-pharmacology/
n12http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n15http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/chemspider/
n10http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n11http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/chebi/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n7http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n6http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/wikipedia/
n5http://linked.opendata.cz/resource/drugbank/drug/DB00589/identifier/pharmgkb/
n21http://linked.opendata.cz/resource/atc/
n20http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00589
rdf:type
n3:Drug
n3:description
An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists). [PubChem]
n3:group
approved
n3:indication
For the management of Parkinson's Disease
owl:sameAs
n10:DB00589 n12:DB00589
dcterms:title
Lisuride
adms:identifier
n5:PA164749019 n6:Lisuride n11:51164 n13:227 n14:227 n15:26847 n16:DB00589 n17:46505557 n18:D08132 n19:28864
n3:mechanismOfAction
Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor. Lisuride is also used to lower prolactin and, in low doses, to prevent migraine attacks.
n3:synonym
Lisuridum Lisurid Lisuride Lisurida N'-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethylurea
n3:proteinBinding
about 15%
n3:salt
n3:IUPAC-Name
n7:271B50F2-363D-11E5-9242-09173F13E4C5
n3:InChI
n7:271B50F8-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n7:271B50F7-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n7:271B50F4-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n7:271B50F5-363D-11E5-9242-09173F13E4C5
n3:SMILES
n7:271B50F6-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n7:271B50F0-363D-11E5-9242-09173F13E4C5
n3:logP
n7:271B5108-363D-11E5-9242-09173F13E4C5 n7:271B50F1-363D-11E5-9242-09173F13E4C5 n7:271B50EE-363D-11E5-9242-09173F13E4C5
n3:logS
n7:271B50EF-363D-11E5-9242-09173F13E4C5
n20:hasATCCode
n21:N02CA07 n21:G02CB02
n3:H-Bond-Acceptor-Count
n7:271B50FE-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n7:271B50FF-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n7:271B50F9-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n7:271B50FA-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n7:271B50FC-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n7:271B50FB-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n7:271B50FD-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
18016-80-3
n3:category
n3:Bioavailability
n7:271B5104-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n7:271B5106-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n7:271B5107-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n7:271B5103-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n7:271B5102-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n7:271B5105-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n7:271B50F3-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n7:271B5100-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n7:271B5101-363D-11E5-9242-09173F13E4C5