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Namespace Prefixes

PrefixIRI
n18http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/drugbank/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n21http://linked.opendata.cz/resource/AHFS/
n15http://linked.opendata.cz/resource/drugbank/company/
n6http://linked.opendata.cz/resource/drugbank/mixture/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/chemspider/
n11http://bio2rdf.org/drugbank:
n10http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/chebi/
admshttp://www.w3.org/ns/adms#
n24http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/wikipedia/
n8http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/pharmgkb/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n20http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n19http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/kegg-compound/
n5http://linked.opendata.cz/ontology/drugbank/
n13http://linked.opendata.cz/resource/drugbank/property/
n14http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/pubchem-compound/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/pubchem-substance/
n4http://linked.opendata.cz/resource/atc/
n17http://linked.opendata.cz/resource/drugbank/drug/DB00576/identifier/kegg-drug/
n3http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00576
rdf:type
n5:Drug
n5:description
A sulfathiazole antibacterial agent. [PubChem]
n5:generalReferences
# Ratanajamit C, Skriver MV, Norgaard M, Jepsen P, Schonheyder HC, Sorensen HT: Adverse pregnancy outcome in users of sulfamethizole during pregnancy: a population-based observational study. J Antimicrob Chemother. 2003 Nov;52(5):837-41. Epub 2003 Sep 30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14519675 # Kerrn MB, Frimodt-Moller N, Espersen F: Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother. 2003 Mar;47(3):1002-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12604534 # Watanabe H, Hastings JW: Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990 Jun 26;1017(3):229-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2372557
n5:group
approved
n5:halfLife
3-8 hours
n5:indication
For the treatment of urinary tract infection
n5:manufacturer
n15:271B4CF4-363D-11E5-9242-09173F13E4C5 n15:271B4CF5-363D-11E5-9242-09173F13E4C5
owl:sameAs
n8:DB00576 n11:DB00576
dcterms:title
Sulfamethizole
adms:identifier
n10:9331 n12:5137 n14:5328 n16:46508656 n17:D00870 n18:DB00576 n19:C08050 n23:PA164781307 n24:Sulfamethizole
n5:mechanismOfAction
Sulfamethizole is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
n5:packager
n15:271B4CF2-363D-11E5-9242-09173F13E4C5 n15:271B4CF3-363D-11E5-9242-09173F13E4C5 n15:271B4CF1-363D-11E5-9242-09173F13E4C5
n5:synonym
Sulfamethizolum Sulfametizol Sulfamethylthiadiazole Sulfamethizol Sulfamethizole Rufol Sulfaméthizol
n3:hasAHFSCode
n21:52-10-00
n5:mixture
n6:271B4CEC-363D-11E5-9242-09173F13E4C5 n6:271B4CED-363D-11E5-9242-09173F13E4C5 n6:271B4CF0-363D-11E5-9242-09173F13E4C5 n6:271B4CEE-363D-11E5-9242-09173F13E4C5 n6:271B4CEF-363D-11E5-9242-09173F13E4C5
n5:proteinBinding
98-99%
n5:IUPAC-Name
n13:271B4CFE-363D-11E5-9242-09173F13E4C5
n5:InChI
n13:271B4D04-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n13:271B4D03-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n13:271B4D00-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n13:271B4D01-363D-11E5-9242-09173F13E4C5
n5:SMILES
n13:271B4D02-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n13:271B4D14-363D-11E5-9242-09173F13E4C5 n13:271B4CFC-363D-11E5-9242-09173F13E4C5
n5:logP
n13:271B4D16-363D-11E5-9242-09173F13E4C5 n13:271B4CFA-363D-11E5-9242-09173F13E4C5 n13:271B4CFD-363D-11E5-9242-09173F13E4C5
n5:logS
n13:271B4D17-363D-11E5-9242-09173F13E4C5 n13:271B4CFB-363D-11E5-9242-09173F13E4C5
n3:hasATCCode
n4:S01AB01 n4:J01EB02 n4:B05CA04 n4:D06BA04
n5:H-Bond-Acceptor-Count
n13:271B4D0A-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n13:271B4D0B-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n13:271B4D05-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n13:271B4D06-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n13:271B4D08-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n13:271B4D07-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n13:271B4D09-363D-11E5-9242-09173F13E4C5
n5:absorption
Rapidly absorbed.
n5:affectedOrganism
Enteric bacteria and other eubacteria
n5:casRegistryNumber
144-82-1
n5:category
n5:containedIn
n20:271B4CF6-363D-11E5-9242-09173F13E4C5 n20:271B4CF9-363D-11E5-9242-09173F13E4C5 n20:271B4CF7-363D-11E5-9242-09173F13E4C5 n20:271B4CF8-363D-11E5-9242-09173F13E4C5
n5:Bioavailability
n13:271B4D10-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n13:271B4D12-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n13:271B4D13-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n13:271B4D15-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n13:271B4D0F-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n13:271B4D0E-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n13:271B4D11-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n13:271B4CFF-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n13:271B4D0C-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n13:271B4D0D-363D-11E5-9242-09173F13E4C5