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Namespace Prefixes

PrefixIRI
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n12http://linked.opendata.cz/resource/drugbank/drug/DB00556/identifier/pharmgkb/
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n22http://linked.opendata.cz/resource/drugbank/company/
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n17http://linked.opendata.cz/resource/drugbank/dosage/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00556/identifier/kegg-drug/
n19http://bio2rdf.org/drugbank:
n18http://linked.opendata.cz/resource/drugbank/drug/DB00556/identifier/drugbank/
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n20http://www.drugs.com/cdi/
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n11http://linked.opendata.cz/resource/drugbank/drug/DB00556/identifier/chebi/
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n23http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00556
rdf:type
n3:Drug
n3:description
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
n3:dosage
n17:271B466E-363D-11E5-9242-09173F13E4C5 n17:271B466F-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Quinones A, Benenstein R, Saric M: New-Onset Seizure after Perflutren Microbubble Injection during Dobutamine Stress Echocardiography. Echocardiography. 2013 Feb 22. doi: 10.1111/echo.12149. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23432576
n3:group
approved
n3:halfLife
The mean half-life of OFP in blood 1.9 minutes
n3:indication
Used as an ultrasound contrast imaging in cardiology and radiology.
n3:manufacturer
n22:271B466C-363D-11E5-9242-09173F13E4C5
owl:sameAs
n15:DB00556 n19:DB00556
dcterms:title
Perflutren
adms:identifier
n5:Octafluoropropane n11:31980 n12:PA164781354 n13:11994-011-04 n16:D01738 n18:DB00556
n3:mechanismOfAction
Perflutren is comprised of gas-filled microspheres that are injected or infused into the body. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the resulting ultrasound image. During echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an improved image that may enable physicians to better diagnose patients.
n3:packager
n22:271B4669-363D-11E5-9242-09173F13E4C5 n22:271B466A-363D-11E5-9242-09173F13E4C5 n22:271B4668-363D-11E5-9242-09173F13E4C5 n22:271B466B-363D-11E5-9242-09173F13E4C5
n3:patent
n6:2107466 n6:6146657 n6:6033645 n6:2256592
n3:synonym
1,1,1,2,2,3,3,3-Octafluoropropane FC 218 Definity Octafluorpropan Oktafluorpropan Freon 218 Perfluoropropane Octafluoropropane Perflutren
n3:toxicity
There is new temporal evidence that perflutren may be associated with new-onset seizure activity following perflutren microbubble contrast injection during dobutamine-atropine stress echocardiography. [PMID: 23432576]
n23:hasAHFSCode
n24:92-00-00
n3:synthesisReference
James L. Webster, Steven H. Swearingen, Douglas W. Bruhnke, Leo E. Manzer, Elrey L. McCann, "Synthesis of perfluoropropane." U.S. Patent US5220083, issued August, 1967.
foaf:page
n8:definity.htm n20:perflutren-lipid-microspheres.html
n3:IUPAC-Name
n9:271B4674-363D-11E5-9242-09173F13E4C5
n3:InChI
n9:271B467A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n9:271B4679-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n9:271B4676-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n9:271B4677-363D-11E5-9242-09173F13E4C5
n3:SMILES
n9:271B4678-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n9:271B4672-363D-11E5-9242-09173F13E4C5 n9:271B4688-363D-11E5-9242-09173F13E4C5
n3:logP
n9:271B4670-363D-11E5-9242-09173F13E4C5 n9:271B4673-363D-11E5-9242-09173F13E4C5 n9:271B468B-363D-11E5-9242-09173F13E4C5
n3:logS
n9:271B4671-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n9:271B4680-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n9:271B4681-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n9:271B467B-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n9:271B467C-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n9:271B467E-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n9:271B467D-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n9:271B467F-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
76-19-7
n3:category
n3:containedIn
n21:271B466D-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n9:271B4684-363D-11E5-9242-09173F13E4C5
n3:Boiling-Point
n9:271B468A-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n9:271B4686-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n9:271B4687-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n9:271B4689-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n9:271B4683-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n9:271B4682-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n9:271B4685-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n9:271B4675-363D-11E5-9242-09173F13E4C5