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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n26http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/wikipedia/
n25http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/pharmgkb/
n20http://linked.opendata.cz/resource/AHFS/
n14http://linked.opendata.cz/resource/mesh/concept/
foafhttp://xmlns.com/foaf/0.1/
n4http://linked.opendata.cz/resource/drugbank/company/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/pdb/
n7http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/kegg-compound/
n21http://linked.opendata.cz/resource/drugbank/dosage/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/pubchem-compound/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/pubchem-substance/
n29http://bio2rdf.org/drugbank:
n8http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/kegg-drug/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/drugbank/
admshttp://www.w3.org/ns/adms#
n17http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/national-drug-code-directory/
n31http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/resource/drugbank/medicinal-product/
n13http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n24http://www.drugs.com/cdi/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/chemspider/
n23http://www.rxlist.com/cgi/generic2/
n5http://linked.opendata.cz/resource/drugbank/property/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00553/identifier/chebi/
xsdhhttp://www.w3.org/2001/XMLSchema#
n30http://linked.opendata.cz/resource/atc/
n19http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00553
rdf:type
n3:Drug
n3:description
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]
n3:dosage
n21:271B453F-363D-11E5-9242-09173F13E4C5 n21:271B453C-363D-11E5-9242-09173F13E4C5 n21:271B453D-363D-11E5-9242-09173F13E4C5 n21:271B453E-363D-11E5-9242-09173F13E4C5 n21:271B4540-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
Approximately 2 hours
n3:indication
For the treatment of psoriasis and vitiligo
n3:manufacturer
n4:271B4533-363D-11E5-9242-09173F13E4C5 n4:271B4531-363D-11E5-9242-09173F13E4C5 n4:271B4532-363D-11E5-9242-09173F13E4C5
owl:sameAs
n29:DB00553 n31:DB00553
dcterms:title
Methoxsalen
adms:identifier
n7:C01864 n8:D00139 n9:DB00553 n10:18358 n11:3971 n15:4114 n16:46506275 n17:0187-0651-42 n18:8MO n25:PA450433 n26:Methoxsalen
n3:mechanismOfAction
After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
n3:packager
n4:271B452B-363D-11E5-9242-09173F13E4C5 n4:271B452C-363D-11E5-9242-09173F13E4C5 n4:271B452A-363D-11E5-9242-09173F13E4C5 n4:271B452F-363D-11E5-9242-09173F13E4C5 n4:271B4530-363D-11E5-9242-09173F13E4C5 n4:271B452D-363D-11E5-9242-09173F13E4C5 n4:271B452E-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
In both mice and man, methoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours (Pathak et al. 1977).
n3:synonym
Methoxsalen 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone Ultra mop 8-Methoxyfuranocoumarin Xanthotoxine Uvadex Methoxalen 8-MOP Xanthotoxin Méthoxsalène Oxsoralen Meladinine 8-Methoxy-2',3',6,7-furocoumarin Xanthoxin Zanthotoxin Meloxine 8-MP 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one 8-Methoxypsoralen O-Methylxanthotoxol Ammoidin 8-Methoxy-[furano-3'.2':6.7-coumarin] 8-Methoxy-4',5':6,7-furocoumarin
n19:hasAHFSCode
n20:84-50-06
n3:foodInteraction
Take with food or milk, or in two divided doses 30 minutes apart to decrease nausea.
n13:hasConcept
n14:M0013600
foaf:page
n23:methox.htm n24:methoxsalen-hard-gelatin-capsules.html
n3:IUPAC-Name
n5:271B4545-363D-11E5-9242-09173F13E4C5
n3:InChI
n5:271B454B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n5:271B454A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B4547-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n5:271B4548-363D-11E5-9242-09173F13E4C5
n3:SMILES
n5:271B4549-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n5:271B4543-363D-11E5-9242-09173F13E4C5 n5:271B455A-363D-11E5-9242-09173F13E4C5
n3:logP
n5:271B4541-363D-11E5-9242-09173F13E4C5 n5:271B4544-363D-11E5-9242-09173F13E4C5 n5:271B455C-363D-11E5-9242-09173F13E4C5
n3:logS
n5:271B4542-363D-11E5-9242-09173F13E4C5 n5:271B455D-363D-11E5-9242-09173F13E4C5
n19:hasATCCode
n30:D05AD02 n30:D05BA02
n3:H-Bond-Acceptor-Count
n5:271B4551-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n5:271B4552-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n5:271B454C-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n5:271B454D-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n5:271B454F-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n5:271B454E-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n5:271B4550-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
298-81-7
n3:category
n3:containedIn
n12:271B4534-363D-11E5-9242-09173F13E4C5 n12:271B4535-363D-11E5-9242-09173F13E4C5 n12:271B4538-363D-11E5-9242-09173F13E4C5 n12:271B4539-363D-11E5-9242-09173F13E4C5 n12:271B4536-363D-11E5-9242-09173F13E4C5 n12:271B4537-363D-11E5-9242-09173F13E4C5 n12:271B453A-363D-11E5-9242-09173F13E4C5 n12:271B453B-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n5:271B4556-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n5:271B4558-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n5:271B4559-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n5:271B455B-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n5:271B4555-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n5:271B4554-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n5:271B4557-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n5:271B4546-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n5:271B4553-363D-11E5-9242-09173F13E4C5