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Namespace Prefixes

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Statements

Subject Item
n2:DB00525
rdf:type
n3:Drug
n3:description
Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.
n3:dosage
n4:271B3EAB-363D-11E5-9242-09173F13E4C5 n4:271B3EAC-363D-11E5-9242-09173F13E4C5 n4:271B3EAD-363D-11E5-9242-09173F13E4C5 n4:271B3EA7-363D-11E5-9242-09173F13E4C5 n4:271B3EB5-363D-11E5-9242-09173F13E4C5 n4:271B3EB6-363D-11E5-9242-09173F13E4C5 n4:271B3EB7-363D-11E5-9242-09173F13E4C5 n4:271B3EA5-363D-11E5-9242-09173F13E4C5 n4:271B3EA6-363D-11E5-9242-09173F13E4C5 n4:271B3EA8-363D-11E5-9242-09173F13E4C5 n4:271B3EA9-363D-11E5-9242-09173F13E4C5 n4:271B3EA3-363D-11E5-9242-09173F13E4C5 n4:271B3EA4-363D-11E5-9242-09173F13E4C5 n4:271B3ECC-363D-11E5-9242-09173F13E4C5 n4:271B3EC5-363D-11E5-9242-09173F13E4C5 n4:271B3EC6-363D-11E5-9242-09173F13E4C5 n4:271B3ECA-363D-11E5-9242-09173F13E4C5 n4:271B3ECB-363D-11E5-9242-09173F13E4C5 n4:271B3EC1-363D-11E5-9242-09173F13E4C5 n4:271B3EC2-363D-11E5-9242-09173F13E4C5 n4:271B3EC3-363D-11E5-9242-09173F13E4C5 n4:271B3EC4-363D-11E5-9242-09173F13E4C5 n4:271B3EBD-363D-11E5-9242-09173F13E4C5 n4:271B3EBE-363D-11E5-9242-09173F13E4C5 n4:271B3EBF-363D-11E5-9242-09173F13E4C5 n4:271B3EC0-363D-11E5-9242-09173F13E4C5 n4:271B3EC7-363D-11E5-9242-09173F13E4C5 n4:271B3EB2-363D-11E5-9242-09173F13E4C5 n4:271B3EC8-363D-11E5-9242-09173F13E4C5 n4:271B3EB3-363D-11E5-9242-09173F13E4C5 n4:271B3EC9-363D-11E5-9242-09173F13E4C5 n4:271B3EB4-363D-11E5-9242-09173F13E4C5 n4:271B3EBC-363D-11E5-9242-09173F13E4C5 n4:271B3EB8-363D-11E5-9242-09173F13E4C5 n4:271B3EAE-363D-11E5-9242-09173F13E4C5 n4:271B3EB9-363D-11E5-9242-09173F13E4C5 n4:271B3EAF-363D-11E5-9242-09173F13E4C5 n4:271B3EBA-363D-11E5-9242-09173F13E4C5 n4:271B3EB0-363D-11E5-9242-09173F13E4C5 n4:271B3EBB-363D-11E5-9242-09173F13E4C5 n4:271B3EB1-363D-11E5-9242-09173F13E4C5 n4:271B3EAA-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8852337 # Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3524433
n3:group
approved
n3:indication
Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
owl:sameAs
n6:DB00525 n21:DB00525
dcterms:title
Tolnaftate
adms:identifier
n8:D00381 n10:5309 n11:DB00525 n12:Tolnaftate n13:46505456 n15:PA164752438 n17:5510 n26:50201633
n3:mechanismOfAction
Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
n3:packager
n25:271B3E97-363D-11E5-9242-09173F13E4C5 n25:271B3E98-363D-11E5-9242-09173F13E4C5 n25:271B3E96-363D-11E5-9242-09173F13E4C5 n25:271B3E99-363D-11E5-9242-09173F13E4C5 n25:271B3E9A-363D-11E5-9242-09173F13E4C5
n3:synonym
Tolnaftatum Tinactin 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate N-Methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester Separin Tolnaphthate O-2-Naphthyl m,N-dimethylthiocarbanilate Tolnaftato Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
n3:toxicity
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
n18:hasAHFSCode
n19:84-04-08-40
n3:mixture
n9:271B3E95-363D-11E5-9242-09173F13E4C5
n3:synthesisReference
Chris E. Platt, "Topical preparation of tolnaftate and hydrocortisone to treat fungal infections of the skin." U.S. Patent US5496812, issued November, 1989.
foaf:page
n24:tolnaftate-cream.html
n3:IUPAC-Name
n14:271B3ED1-363D-11E5-9242-09173F13E4C5
n3:InChI
n14:271B3ED7-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n14:271B3ED6-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n14:271B3ED3-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n14:271B3ED4-363D-11E5-9242-09173F13E4C5
n3:SMILES
n14:271B3ED5-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n14:271B3ECF-363D-11E5-9242-09173F13E4C5 n14:271B3EE6-363D-11E5-9242-09173F13E4C5
n3:logP
n14:271B3EE8-363D-11E5-9242-09173F13E4C5 n14:271B3ED0-363D-11E5-9242-09173F13E4C5 n14:271B3ECD-363D-11E5-9242-09173F13E4C5
n3:logS
n14:271B3ECE-363D-11E5-9242-09173F13E4C5
n18:hasATCCode
n20:D01AE18
n3:H-Bond-Acceptor-Count
n14:271B3EDD-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n14:271B3EDE-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n14:271B3ED8-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n14:271B3ED9-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n14:271B3EDB-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n14:271B3EDA-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n14:271B3EDC-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Yeast and other fungi
n3:casRegistryNumber
2398-96-1
n3:category
n3:containedIn
n16:271B3EA2-363D-11E5-9242-09173F13E4C5 n16:271B3EA0-363D-11E5-9242-09173F13E4C5 n16:271B3EA1-363D-11E5-9242-09173F13E4C5 n16:271B3E9E-363D-11E5-9242-09173F13E4C5 n16:271B3E9F-363D-11E5-9242-09173F13E4C5 n16:271B3E9D-363D-11E5-9242-09173F13E4C5 n16:271B3E9B-363D-11E5-9242-09173F13E4C5 n16:271B3E9C-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n14:271B3EE2-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n14:271B3EE4-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n14:271B3EE5-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n14:271B3EE7-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n14:271B3EE1-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n14:271B3EE0-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n14:271B3EE3-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n14:271B3ED2-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n14:271B3EDF-363D-11E5-9242-09173F13E4C5