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Namespace Prefixes

PrefixIRI
n13http://linked.opendata.cz/resource/drugbank/drug/DB00505/identifier/chebi/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n17http://linked.opendata.cz/resource/drugbank/company/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00505/identifier/pharmgkb/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00505/identifier/kegg-compound/
n7http://bio2rdf.org/drugbank:
n16http://linked.opendata.cz/resource/drugbank/drug/DB00505/identifier/pubchem-compound/
admshttp://www.w3.org/ns/adms#
n14http://linked.opendata.cz/resource/drugbank/drug/DB00505/identifier/pubchem-substance/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00505/identifier/drugbank/
n4http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/drugbank/
owlhttp://www.w3.org/2002/07/owl#
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n10http://linked.opendata.cz/resource/drugbank/drug/DB00505/identifier/chemspider/

Statements

Subject Item
n2:DB00505
rdf:type
n5:Drug
n5:description
Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.
n5:group
withdrawn
n5:indication
Used as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus
n5:manufacturer
n17:271B61DF-363D-11E5-9242-09173F13E4C5
owl:sameAs
n4:DB00505 n7:DB00505
dcterms:title
Tridihexethyl
adms:identifier
n10:19124 n11:DB00505 n12:PA164746229 n13:9701 n14:46506672 n15:C07861 n16:20299
n5:mechanismOfAction
Tridihexethyl binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
n5:IUPAC-Name
n6:271B61E4-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B61EA-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B61E9-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B61E6-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B61E7-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B61E8-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B61E2-363D-11E5-9242-09173F13E4C5 n6:271B61FA-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B61E3-363D-11E5-9242-09173F13E4C5 n6:271B61E0-363D-11E5-9242-09173F13E4C5 n6:271B61FC-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B61E1-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Acceptor-Count
n6:271B61F0-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B61F1-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B61EB-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B61EC-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B61EE-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B61ED-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B61EF-363D-11E5-9242-09173F13E4C5
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
60-49-1
n5:category
n5:Bioavailability
n6:271B61F6-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B61F8-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B61F9-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n6:271B61FB-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B61F5-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B61F4-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B61F7-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B61E5-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n6:271B61F2-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B61F3-363D-11E5-9242-09173F13E4C5