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Namespace Prefixes

PrefixIRI
n18http://linked.opendata.cz/resource/drugbank/drug/DB00504/identifier/kegg-compound/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00504/identifier/pubchem-compound/
n9http://linked.opendata.cz/resource/drugbank/company/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00504/identifier/pubchem-substance/
n10http://linked.opendata.cz/resource/drugbank/mixture/
n17http://linked.opendata.cz/resource/drugbank/drug/DB00504/identifier/drugbank/
n13http://bio2rdf.org/drugbank:
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n14http://linked.opendata.cz/resource/drugbank/drug/DB00504/identifier/chemspider/
n12http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
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owlhttp://www.w3.org/2002/07/owl#
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n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n8http://linked.opendata.cz/resource/drugbank/drug/DB00504/identifier/wikipedia/
n6http://linked.opendata.cz/resource/drugbank/drug/DB00504/identifier/pharmgkb/

Statements

Subject Item
n2:DB00504
rdf:type
n3:Drug
n3:description
An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
n3:group
approved
n3:halfLife
1 hour
n3:indication
For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
n3:manufacturer
n9:271B61C1-363D-11E5-9242-09173F13E4C5
owl:sameAs
n12:DB00504 n13:DB00504
dcterms:title
Levallorphan
adms:identifier
n6:PA164749284 n8:Levallorphan n14:4514267 n15:5359371 n16:46505682 n17:DB00504 n18:C07069
n3:mechanismOfAction
Levallorphan antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3.
n3:synonym
Levalorfano Naloxiphan Levallofano SID144205558 LĂ©vallorphane Levallorphanum Lorfan Levallorphan
n3:toxicity
Oral, rat LD<sub>50</sub>: 109&plusmn;4 mg/kg
n3:mixture
n10:271B61C0-363D-11E5-9242-09173F13E4C5
n3:salt
n3:IUPAC-Name
n4:271B61C6-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B61CC-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B61CB-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B61C8-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B61C9-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B61CA-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B61C4-363D-11E5-9242-09173F13E4C5 n4:271B61DC-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B61DE-363D-11E5-9242-09173F13E4C5 n4:271B61C2-363D-11E5-9242-09173F13E4C5 n4:271B61C5-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B61C3-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B61D2-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B61D3-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B61CD-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B61CE-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B61D0-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B61CF-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B61D1-363D-11E5-9242-09173F13E4C5
n3:absorption
Rapidly absorbed.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
152-02-3
n3:category
n3:Bioavailability
n4:271B61D8-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B61DA-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B61DB-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B61DD-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B61D7-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B61D6-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B61D9-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B61C7-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B61D4-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B61D5-363D-11E5-9242-09173F13E4C5