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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/chebi/
n17http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/wikipedia/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/pharmgkb/
n14http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/pubchem-compound/
n6http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n13http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/kegg-drug/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/pubchem-substance/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/drugbank/
n16http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/sukl/drug/
n19http://linked.opendata.cz/resource/atc/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00487/identifier/chemspider/

Statements

Subject Item
n2:DB00487
rdf:type
n3:Drug
n3:description
A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria. [PubChem]
n3:group
approved
n3:halfLife
8.6 hours
n3:indication
For the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
owl:sameAs
n6:DB00487 n16:DB00487
dcterms:title
Pefloxacin
adms:identifier
n8:46291 n9:DB00487 n10:50199 n11:46507338 n13:D02306 n14:51081 n15:PA164742856 n17:Pefloxacin
n3:mechanismOfAction
The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.
n3:synonym
PFLX Pefloxacin Pefloxacinum Labocton Pefloxacine Pefloxacino
n3:toxicity
Adverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure.
n3:proteinBinding
20-30%
n3:salt
n3:synthesisReference
"DrugSyn.org":http://www.drugsyn.org/Pefloxacin.htm
n3:IUPAC-Name
n4:271B5C42-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5C48-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5C47-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5C44-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5C45-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5C46-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5C40-363D-11E5-9242-09173F13E4C5 n4:271B5C58-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5C5A-363D-11E5-9242-09173F13E4C5 n4:271B5C3E-363D-11E5-9242-09173F13E4C5 n4:271B5C41-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5C3F-363D-11E5-9242-09173F13E4C5
n18:hasATCCode
n19:J01MA03
n3:H-Bond-Acceptor-Count
n4:271B5C4E-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5C4F-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5C49-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5C4A-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5C4C-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5C4B-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5C4D-363D-11E5-9242-09173F13E4C5
n3:absorption
Well absorbed by the oral route.
n3:affectedOrganism
Enteric bacteria and other eubacteria
n3:casRegistryNumber
70458-92-3
n3:category
n3:Bioavailability
n4:271B5C54-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5C56-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B5C57-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B5C59-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5C53-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5C52-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5C55-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5C43-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5C50-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5C51-363D-11E5-9242-09173F13E4C5