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Namespace Prefixes

PrefixIRI
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n4http://linked.opendata.cz/resource/drugbank/property/
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n26http://linked.opendata.cz/resource/drugbank/drug/DB00415/identifier/drugbank/
n14http://linked.opendata.cz/resource/atc/
n13http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00415
rdf:type
n3:Drug
n3:description
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. [PubChem]
n3:dosage
n10:271B47A8-363D-11E5-9242-09173F13E4C5 n10:271B47A9-363D-11E5-9242-09173F13E4C5 n10:271B47AA-363D-11E5-9242-09173F13E4C5 n10:271B4798-363D-11E5-9242-09173F13E4C5 n10:271B4799-363D-11E5-9242-09173F13E4C5 n10:271B479A-363D-11E5-9242-09173F13E4C5 n10:271B479B-363D-11E5-9242-09173F13E4C5 n10:271B479C-363D-11E5-9242-09173F13E4C5 n10:271B479D-363D-11E5-9242-09173F13E4C5 n10:271B479E-363D-11E5-9242-09173F13E4C5 n10:271B479F-363D-11E5-9242-09173F13E4C5 n10:271B47A0-363D-11E5-9242-09173F13E4C5 n10:271B47A1-363D-11E5-9242-09173F13E4C5 n10:271B47A2-363D-11E5-9242-09173F13E4C5 n10:271B47A3-363D-11E5-9242-09173F13E4C5 n10:271B47A4-363D-11E5-9242-09173F13E4C5 n10:271B47A5-363D-11E5-9242-09173F13E4C5 n10:271B47A6-363D-11E5-9242-09173F13E4C5 n10:271B47A7-363D-11E5-9242-09173F13E4C5 n10:271B4797-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
n3:manufacturer
n5:271B477A-363D-11E5-9242-09173F13E4C5 n5:271B4781-363D-11E5-9242-09173F13E4C5 n5:271B4782-363D-11E5-9242-09173F13E4C5 n5:271B477F-363D-11E5-9242-09173F13E4C5 n5:271B4780-363D-11E5-9242-09173F13E4C5 n5:271B477D-363D-11E5-9242-09173F13E4C5 n5:271B477E-363D-11E5-9242-09173F13E4C5 n5:271B477B-363D-11E5-9242-09173F13E4C5 n5:271B477C-363D-11E5-9242-09173F13E4C5 n5:271B4789-363D-11E5-9242-09173F13E4C5 n5:271B4787-363D-11E5-9242-09173F13E4C5 n5:271B4773-363D-11E5-9242-09173F13E4C5 n5:271B4788-363D-11E5-9242-09173F13E4C5 n5:271B4774-363D-11E5-9242-09173F13E4C5 n5:271B4785-363D-11E5-9242-09173F13E4C5 n5:271B4771-363D-11E5-9242-09173F13E4C5 n5:271B4786-363D-11E5-9242-09173F13E4C5 n5:271B4772-363D-11E5-9242-09173F13E4C5 n5:271B4783-363D-11E5-9242-09173F13E4C5 n5:271B4784-363D-11E5-9242-09173F13E4C5 n5:271B4770-363D-11E5-9242-09173F13E4C5 n5:271B4779-363D-11E5-9242-09173F13E4C5 n5:271B4777-363D-11E5-9242-09173F13E4C5 n5:271B4778-363D-11E5-9242-09173F13E4C5 n5:271B4775-363D-11E5-9242-09173F13E4C5 n5:271B4776-363D-11E5-9242-09173F13E4C5
owl:sameAs
n17:DB00415 n30:DB00415
dcterms:title
Ampicillin
adms:identifier
n9:Ampicillin n18:28971 n19:6013 n20:PA448419 n21:6249 n22:0781-3412-92 n23:AIC n24:C06574 n25:D00204 n26:DB00415 n29:46505346
n3:mechanismOfAction
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor.
n3:packager
n5:271B4767-363D-11E5-9242-09173F13E4C5 n5:271B4768-363D-11E5-9242-09173F13E4C5 n5:271B4765-363D-11E5-9242-09173F13E4C5 n5:271B4766-363D-11E5-9242-09173F13E4C5 n5:271B476B-363D-11E5-9242-09173F13E4C5 n5:271B476C-363D-11E5-9242-09173F13E4C5 n5:271B4769-363D-11E5-9242-09173F13E4C5 n5:271B476A-363D-11E5-9242-09173F13E4C5 n5:271B4748-363D-11E5-9242-09173F13E4C5 n5:271B4749-363D-11E5-9242-09173F13E4C5 n5:271B4746-363D-11E5-9242-09173F13E4C5 n5:271B4747-363D-11E5-9242-09173F13E4C5 n5:271B4763-363D-11E5-9242-09173F13E4C5 n5:271B4764-363D-11E5-9242-09173F13E4C5 n5:271B474A-363D-11E5-9242-09173F13E4C5 n5:271B474B-363D-11E5-9242-09173F13E4C5 n5:271B4744-363D-11E5-9242-09173F13E4C5 n5:271B4745-363D-11E5-9242-09173F13E4C5 n5:271B4742-363D-11E5-9242-09173F13E4C5 n5:271B4743-363D-11E5-9242-09173F13E4C5 n5:271B474F-363D-11E5-9242-09173F13E4C5 n5:271B4750-363D-11E5-9242-09173F13E4C5 n5:271B474D-363D-11E5-9242-09173F13E4C5 n5:271B474E-363D-11E5-9242-09173F13E4C5 n5:271B474C-363D-11E5-9242-09173F13E4C5 n5:271B4761-363D-11E5-9242-09173F13E4C5 n5:271B4762-363D-11E5-9242-09173F13E4C5 n5:271B475B-363D-11E5-9242-09173F13E4C5 n5:271B475C-363D-11E5-9242-09173F13E4C5 n5:271B4759-363D-11E5-9242-09173F13E4C5 n5:271B475A-363D-11E5-9242-09173F13E4C5 n5:271B475F-363D-11E5-9242-09173F13E4C5 n5:271B4760-363D-11E5-9242-09173F13E4C5 n5:271B475D-363D-11E5-9242-09173F13E4C5 n5:271B475E-363D-11E5-9242-09173F13E4C5 n5:271B4753-363D-11E5-9242-09173F13E4C5 n5:271B4754-363D-11E5-9242-09173F13E4C5 n5:271B4751-363D-11E5-9242-09173F13E4C5 n5:271B4752-363D-11E5-9242-09173F13E4C5 n5:271B4757-363D-11E5-9242-09173F13E4C5 n5:271B4758-363D-11E5-9242-09173F13E4C5 n5:271B4755-363D-11E5-9242-09173F13E4C5 n5:271B4756-363D-11E5-9242-09173F13E4C5 n5:271B476F-363D-11E5-9242-09173F13E4C5 n5:271B476D-363D-11E5-9242-09173F13E4C5 n5:271B476E-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
Ampicillin is excreted largely unchanged in the urine.
n3:synonym
(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Anhydrous ampicillin D-(-)-Ampicillin Ampicilina Ampicillin D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid Aminobenzylpenicillin Ampicillinum D-(−)-ampicillin 6-(D-(2-amino-2-Phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid ABPC D-(−)-6-(α-aminophenylacetamido)penicillanic acid AP AMP Ampicillin Anhydrous Ampicilline Ampicillin Acid
n13:hasAHFSCode
n15:08-12-16-08
n3:foodInteraction
Take on an empty stomach.
n3:mixture
n31:271B4740-363D-11E5-9242-09173F13E4C5 n31:271B4741-363D-11E5-9242-09173F13E4C5
n3:salt
n3:synthesisReference
Jean Bouchaudon, Pierre Le Roy, Mayer Naoum Messer, "Process for the preparation of ampicillin." U.S. Patent US3978078, issued December, 1974.
n27:hasConcept
n28:M0001025
foaf:page
n7:ampicillin.html n32:ampicillin.htm
n3:IUPAC-Name
n4:271B47AF-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B47B5-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B47B4-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B47B1-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B47B2-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B47B3-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B47AD-363D-11E5-9242-09173F13E4C5 n4:271B47C5-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B47AE-363D-11E5-9242-09173F13E4C5 n4:271B47AB-363D-11E5-9242-09173F13E4C5 n4:271B47C7-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B47AC-363D-11E5-9242-09173F13E4C5
n13:hasATCCode
n14:S01AA19 n14:J01CA01
n3:H-Bond-Acceptor-Count
n4:271B47BB-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B47BC-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B47B6-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B47B7-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B47B9-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B47B8-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B47BA-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Streptococcus pneumoniae Neisseria meningitidis Streptococcus pyogenes Gram-negative Bacteria Gram-positive Bacteria Enteric bacteria and other eubacteria Listeria monocytogenes Haemophilus influenzae
n3:casRegistryNumber
69-53-4
n3:category
n3:containedIn
n11:271B4795-363D-11E5-9242-09173F13E4C5 n11:271B4796-363D-11E5-9242-09173F13E4C5 n11:271B478B-363D-11E5-9242-09173F13E4C5 n11:271B4790-363D-11E5-9242-09173F13E4C5 n11:271B478A-363D-11E5-9242-09173F13E4C5 n11:271B4793-363D-11E5-9242-09173F13E4C5 n11:271B4794-363D-11E5-9242-09173F13E4C5 n11:271B4791-363D-11E5-9242-09173F13E4C5 n11:271B4792-363D-11E5-9242-09173F13E4C5 n11:271B478E-363D-11E5-9242-09173F13E4C5 n11:271B478F-363D-11E5-9242-09173F13E4C5 n11:271B478C-363D-11E5-9242-09173F13E4C5 n11:271B478D-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B47C1-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B47C3-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B47C4-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B47C6-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B47C0-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B47BF-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B47C2-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B47B0-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B47BD-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B47BE-363D-11E5-9242-09173F13E4C5