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Namespace Prefixes

PrefixIRI
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n2http://linked.opendata.cz/resource/drugbank/drug/
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n13http://linked.opendata.cz/resource/drugbank/drug/DB00389/identifier/pubchem-substance/
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n6http://bio2rdf.org/drugbank:
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n9http://linked.opendata.cz/resource/drugbank/drug/DB00389/identifier/wikipedia/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00389/identifier/pharmgkb/
n21http://linked.opendata.cz/resource/atc/
n20http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00389
rdf:type
n3:Drug
n3:description
An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity. [PubChem]
n3:group
approved
n3:indication
For the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy.
owl:sameAs
n6:DB00389 n19:DB00389
dcterms:title
Carbimazole
adms:identifier
n8:PA164742970 n9:Carbimazole n10:28829 n11:DB00389 n12:617099 n13:46506359 n14:C07615 n17:31072
n3:mechanismOfAction
Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.
n3:synonym
Carbimazol Carbinazole Thyrostat Ethyl 3-methyl-2-thioimidazoline-1-carboxylate Carbimazolo Carbethoxymethimazole Carbimazolum 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester Ethyl 3-methyl-2-thioimidazoline-1-carboxylate Athyromazole
n3:proteinBinding
85%
n15:hasConcept
n16:M0003346
n3:IUPAC-Name
n4:271B4078-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B407E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B407D-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B407A-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B407B-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B407C-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4076-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4077-363D-11E5-9242-09173F13E4C5 n4:271B4074-363D-11E5-9242-09173F13E4C5 n4:271B408E-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4075-363D-11E5-9242-09173F13E4C5
n20:hasATCCode
n21:H03BB01
n3:H-Bond-Acceptor-Count
n4:271B4084-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4085-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B407F-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4080-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4082-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4081-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4083-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
22232-54-8
n3:category
n3:Bioavailability
n4:271B4089-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B408B-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B408C-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B408D-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4088-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4087-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B408A-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4079-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4086-363D-11E5-9242-09173F13E4C5