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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n14http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/chemspider/
n12http://linked.opendata.cz/resource/AHFS/
n17http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/chebi/
foafhttp://xmlns.com/foaf/0.1/
n26http://linked.opendata.cz/resource/mesh/concept/
n10http://linked.opendata.cz/resource/drugbank/company/
n13http://linked.opendata.cz/resource/drugbank/mixture/
n18http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/pharmgkb/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/wikipedia/
n24http://bio2rdf.org/drugbank:
n19http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/pubchem-compound/
admshttp://www.w3.org/ns/adms#
n6http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n20http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/kegg-drug/
n27http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/pubchem-substance/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n15http://linked.opendata.cz/resource/drugbank/drug/DB00366/identifier/drugbank/
n9http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n25http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n23http://www.drugs.com/cdi/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/resource/atc/
n11http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00366
rdf:type
n3:Drug
n3:description
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]
n3:group
approved
n3:halfLife
10 hours
n3:indication
Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
owl:sameAs
n6:DB00366 n24:DB00366
dcterms:title
Doxylamine
adms:identifier
n8:Doxylamine n14:3050 n15:DB00366 n17:51380 n18:PA449419 n19:3162 n20:D02327 n27:46506354
n3:mechanismOfAction
Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.
n3:packager
n10:271B60D3-363D-11E5-9242-09173F13E4C5 n10:271B60D4-363D-11E5-9242-09173F13E4C5 n10:271B60D7-363D-11E5-9242-09173F13E4C5 n10:271B60D8-363D-11E5-9242-09173F13E4C5 n10:271B60D5-363D-11E5-9242-09173F13E4C5 n10:271B60D6-363D-11E5-9242-09173F13E4C5
n3:synonym
2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine Dossilamina Doxylaminum Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether Doxilminio 2-Dimethylaminoethoxyphenylmethyl-2-picoline Doxilamina
n3:toxicity
Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
n11:hasAHFSCode
n12:04-04-04
n3:mixture
n13:271B60D1-363D-11E5-9242-09173F13E4C5 n13:271B60D2-363D-11E5-9242-09173F13E4C5 n13:271B60CF-363D-11E5-9242-09173F13E4C5 n13:271B60D0-363D-11E5-9242-09173F13E4C5 n13:271B60C5-363D-11E5-9242-09173F13E4C5 n13:271B60C6-363D-11E5-9242-09173F13E4C5 n13:271B60C4-363D-11E5-9242-09173F13E4C5 n13:271B60C9-363D-11E5-9242-09173F13E4C5 n13:271B60CA-363D-11E5-9242-09173F13E4C5 n13:271B60C7-363D-11E5-9242-09173F13E4C5 n13:271B60C8-363D-11E5-9242-09173F13E4C5 n13:271B60CD-363D-11E5-9242-09173F13E4C5 n13:271B60CE-363D-11E5-9242-09173F13E4C5 n13:271B60CB-363D-11E5-9242-09173F13E4C5 n13:271B60CC-363D-11E5-9242-09173F13E4C5
n25:hasConcept
n26:M0006795
foaf:page
n23:doxylamine.html
n3:IUPAC-Name
n4:271B60E0-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B60E6-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B60E5-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B60E2-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B60E3-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B60E4-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B60DE-363D-11E5-9242-09173F13E4C5 n4:271B60F5-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B60DC-363D-11E5-9242-09173F13E4C5 n4:271B60DF-363D-11E5-9242-09173F13E4C5 n4:271B60F8-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B60DD-363D-11E5-9242-09173F13E4C5
n11:hasATCCode
n16:R06AA09
n3:H-Bond-Acceptor-Count
n4:271B60EC-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B60ED-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B60E7-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B60E8-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B60EA-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B60E9-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B60EB-363D-11E5-9242-09173F13E4C5
n3:absorption
Readily absorbed via the gastrointestinal tract.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
469-21-6
n3:category
n3:containedIn
n9:271B60DB-363D-11E5-9242-09173F13E4C5 n9:271B60D9-363D-11E5-9242-09173F13E4C5 n9:271B60DA-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B60F1-363D-11E5-9242-09173F13E4C5
n3:Boiling-Point
n4:271B60F7-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B60F3-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B60F4-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B60F6-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B60F0-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B60EF-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B60F2-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B60E1-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B60EE-363D-11E5-9242-09173F13E4C5