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Namespace Prefixes

PrefixIRI
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dctermshttp://purl.org/dc/terms/
n21http://linked.opendata.cz/resource/drugbank/drug/DB00286/identifier/pubchem-compound/
n7http://linked.opendata.cz/resource/AHFS/
n12http://linked.opendata.cz/resource/mesh/concept/
n17http://linked.opendata.cz/resource/drugbank/company/
foafhttp://xmlns.com/foaf/0.1/
n14http://linked.opendata.cz/resource/drugbank/dosage/
n22http://linked.opendata.cz/resource/drugbank/drug/DB00286/identifier/pubchem-substance/
n13http://linked.opendata.cz/resource/drugbank/mixture/
n25http://linked.opendata.cz/resource/drugbank/drug/DB00286/identifier/drugbank/
n16http://bio2rdf.org/drugbank:
n23http://linked.opendata.cz/resource/drugbank/drug/DB00286/identifier/national-drug-code-directory/
admshttp://www.w3.org/ns/adms#
n9http://www.rxlist.com/cgi/generic/
n26http://linked.opendata.cz/resource/drugbank/patent/
n28http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n24http://linked.opendata.cz/resource/drugbank/drug/DB00286/identifier/chemspider/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/resource/drugbank/medicinal-product/
n11http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n27http://www.drugs.com/cdi/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n19http://linked.opendata.cz/resource/drugbank/drug/DB00286/identifier/pharmgkb/
n20http://linked.opendata.cz/resource/atc/
n6http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00286
rdf:type
n3:Drug
n3:description
Conjugated estrogens, a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics.
n3:dosage
n14:271B4A99-363D-11E5-9242-09173F13E4C5 n14:271B4A9A-363D-11E5-9242-09173F13E4C5 n14:271B4A9B-363D-11E5-9242-09173F13E4C5 n14:271B4A9C-363D-11E5-9242-09173F13E4C5 n14:271B4A9D-363D-11E5-9242-09173F13E4C5 n14:271B4A9E-363D-11E5-9242-09173F13E4C5 n14:271B4A9F-363D-11E5-9242-09173F13E4C5 n14:271B4AA0-363D-11E5-9242-09173F13E4C5 n14:271B4AA1-363D-11E5-9242-09173F13E4C5 n14:271B4AA2-363D-11E5-9242-09173F13E4C5 n14:271B4AA3-363D-11E5-9242-09173F13E4C5 n14:271B4AA4-363D-11E5-9242-09173F13E4C5 n14:271B4AA5-363D-11E5-9242-09173F13E4C5 n14:271B4AA6-363D-11E5-9242-09173F13E4C5 n14:271B4AA7-363D-11E5-9242-09173F13E4C5 n14:271B4AA8-363D-11E5-9242-09173F13E4C5 n14:271B4AA9-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
7.4 hours
n3:indication
For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
n3:manufacturer
n17:271B4A87-363D-11E5-9242-09173F13E4C5 n17:271B4A85-363D-11E5-9242-09173F13E4C5 n17:271B4A86-363D-11E5-9242-09173F13E4C5 n17:271B4A84-363D-11E5-9242-09173F13E4C5
owl:sameAs
n16:DB00286 n28:DB00286
dcterms:title
Conjugated Estrogens
adms:identifier
n19:PA164754789 n21:23667301 n22:46505680 n23:0046-0872-93 n24:9532 n25:DB00286
n3:mechanismOfAction
Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary.
n3:packager
n17:271B4A7B-363D-11E5-9242-09173F13E4C5 n17:271B4A7C-363D-11E5-9242-09173F13E4C5 n17:271B4A79-363D-11E5-9242-09173F13E4C5 n17:271B4A7A-363D-11E5-9242-09173F13E4C5 n17:271B4A7F-363D-11E5-9242-09173F13E4C5 n17:271B4A80-363D-11E5-9242-09173F13E4C5 n17:271B4A7D-363D-11E5-9242-09173F13E4C5 n17:271B4A7E-363D-11E5-9242-09173F13E4C5 n17:271B4A73-363D-11E5-9242-09173F13E4C5 n17:271B4A74-363D-11E5-9242-09173F13E4C5 n17:271B4A71-363D-11E5-9242-09173F13E4C5 n17:271B4A72-363D-11E5-9242-09173F13E4C5 n17:271B4A77-363D-11E5-9242-09173F13E4C5 n17:271B4A78-363D-11E5-9242-09173F13E4C5 n17:271B4A75-363D-11E5-9242-09173F13E4C5 n17:271B4A76-363D-11E5-9242-09173F13E4C5 n17:271B4A83-363D-11E5-9242-09173F13E4C5 n17:271B4A81-363D-11E5-9242-09173F13E4C5 n17:271B4A82-363D-11E5-9242-09173F13E4C5 n17:271B4A5B-363D-11E5-9242-09173F13E4C5 n17:271B4A5C-363D-11E5-9242-09173F13E4C5 n17:271B4A59-363D-11E5-9242-09173F13E4C5 n17:271B4A5A-363D-11E5-9242-09173F13E4C5 n17:271B4A5F-363D-11E5-9242-09173F13E4C5 n17:271B4A60-363D-11E5-9242-09173F13E4C5 n17:271B4A5D-363D-11E5-9242-09173F13E4C5 n17:271B4A5E-363D-11E5-9242-09173F13E4C5 n17:271B4A57-363D-11E5-9242-09173F13E4C5 n17:271B4A58-363D-11E5-9242-09173F13E4C5 n17:271B4A56-363D-11E5-9242-09173F13E4C5 n17:271B4A6B-363D-11E5-9242-09173F13E4C5 n17:271B4A6C-363D-11E5-9242-09173F13E4C5 n17:271B4A69-363D-11E5-9242-09173F13E4C5 n17:271B4A6A-363D-11E5-9242-09173F13E4C5 n17:271B4A6F-363D-11E5-9242-09173F13E4C5 n17:271B4A70-363D-11E5-9242-09173F13E4C5 n17:271B4A6D-363D-11E5-9242-09173F13E4C5 n17:271B4A6E-363D-11E5-9242-09173F13E4C5 n17:271B4A63-363D-11E5-9242-09173F13E4C5 n17:271B4A64-363D-11E5-9242-09173F13E4C5 n17:271B4A61-363D-11E5-9242-09173F13E4C5 n17:271B4A62-363D-11E5-9242-09173F13E4C5 n17:271B4A67-363D-11E5-9242-09173F13E4C5 n17:271B4A68-363D-11E5-9242-09173F13E4C5 n17:271B4A65-363D-11E5-9242-09173F13E4C5 n17:271B4A66-363D-11E5-9242-09173F13E4C5
n3:patent
n26:5908638 n26:5547948
n3:routeOfElimination
Estradiol, estrone, and estriol are excreted in the urine, along with glucuronide and sulfate conjugates. Exogenous estrogens are metabolized in the same manner as endogenous estrogens.
n3:synonym
Estrogens Oestrone-3-sulphate sodium salt Premarin Morestin Estrone sodium sulfate Estrogenic substances (conjugated) 17-Oxoestra-1,3,5(10)-trien-3-yl sodium sulfate Sodium estrone 3-sulfate Estrone-3-sulfate sodium salt Evex Estrone sulfate sodium Conestoral Hyhorin
n3:toxicity
Nausea and vomiting
n6:hasAHFSCode
n7:68-16-04
n3:foodInteraction
Take with food to reduce nausea. Avoid excessive quantities of coffee or tea (Caffeine). Avoid alcohol.
n3:mixture
n13:271B4A54-363D-11E5-9242-09173F13E4C5 n13:271B4A55-363D-11E5-9242-09173F13E4C5
n3:proteinBinding
90% bound to plasma proteins
n3:synthesisReference
Vallapa Soong, "Process for the preparation of conjugated estrogens from pregnant mare urine." U.S. Patent US20020156303, issued October 24, 2002.
n11:hasConcept
n12:M0007792
foaf:page
n9:conest.htm n27:conjugated-estrogens.html
n3:IUPAC-Name
n4:271B4AAE-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4AB4-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4AB3-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4AB0-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4AB1-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4AB2-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4AAC-363D-11E5-9242-09173F13E4C5 n4:271B4AC4-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4AAA-363D-11E5-9242-09173F13E4C5 n4:271B4AAD-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4AAB-363D-11E5-9242-09173F13E4C5
n6:hasATCCode
n20:G03CA57
n3:H-Bond-Acceptor-Count
n4:271B4ABA-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4ABB-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4AB5-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4AB6-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4AB8-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4AB7-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4AB9-363D-11E5-9242-09173F13E4C5
n3:absorption
Well absorbed
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
438-67-5
n3:category
n3:containedIn
n5:271B4A8F-363D-11E5-9242-09173F13E4C5 n5:271B4A90-363D-11E5-9242-09173F13E4C5 n5:271B4A89-363D-11E5-9242-09173F13E4C5 n5:271B4A8A-363D-11E5-9242-09173F13E4C5 n5:271B4A88-363D-11E5-9242-09173F13E4C5 n5:271B4A95-363D-11E5-9242-09173F13E4C5 n5:271B4A96-363D-11E5-9242-09173F13E4C5 n5:271B4A93-363D-11E5-9242-09173F13E4C5 n5:271B4A94-363D-11E5-9242-09173F13E4C5 n5:271B4A97-363D-11E5-9242-09173F13E4C5 n5:271B4A98-363D-11E5-9242-09173F13E4C5 n5:271B4A8D-363D-11E5-9242-09173F13E4C5 n5:271B4A8E-363D-11E5-9242-09173F13E4C5 n5:271B4A8B-363D-11E5-9242-09173F13E4C5 n5:271B4A8C-363D-11E5-9242-09173F13E4C5 n5:271B4A91-363D-11E5-9242-09173F13E4C5 n5:271B4A92-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B4AC0-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4AC2-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4AC3-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B4AC5-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4ABF-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4ABE-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4AC1-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4AAF-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4ABC-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4ABD-363D-11E5-9242-09173F13E4C5