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Namespace Prefixes

PrefixIRI
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n7http://linked.opendata.cz/resource/atc/
n6http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00212
rdf:type
n4:Drug
n4:description
Remikiren is an orally active, high specificity renin inhibitor.
n4:generalReferences
# Clozel JP, Fischli W: Discovery of remikiren as the first orally active renin inhibitor. Arzneimittelforschung. 1993 Feb;43(2A):260-2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8498974 # Richter WF, Whitby BR, Chou RC: Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Xenobiotica. 1996 Mar;26(3):243-54. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8730917
n4:group
approved
n4:indication
For the treatment of hypertension and heart failure
owl:sameAs
n16:DB00212 n20:DB00212
dcterms:title
Remikiren
adms:identifier
n9:PA164774779 n10:Remikiren n13:4575384 n14:DB00212 n17:46507286 n18:C07465 n19:5462340
n4:mechanismOfAction
Several in vivo experiments have shown that remikiren is specific for renin and does not decrease arterial pressure by an unrelated mechanism.
n4:proteinBinding
83%
n11:hasConcept
n12:M0180288
n4:IUPAC-Name
n5:271B5CE6-363D-11E5-9242-09173F13E4C5
n4:InChI
n5:271B5CEC-363D-11E5-9242-09173F13E4C5
n4:Molecular-Formula
n5:271B5CEB-363D-11E5-9242-09173F13E4C5
n4:Molecular-Weight
n5:271B5CE8-363D-11E5-9242-09173F13E4C5
n4:Monoisotopic-Weight
n5:271B5CE9-363D-11E5-9242-09173F13E4C5
n4:SMILES
n5:271B5CEA-363D-11E5-9242-09173F13E4C5
n4:Water-Solubility
n5:271B5CE4-363D-11E5-9242-09173F13E4C5
n4:logP
n5:271B5CFC-363D-11E5-9242-09173F13E4C5 n5:271B5CE2-363D-11E5-9242-09173F13E4C5 n5:271B5CE5-363D-11E5-9242-09173F13E4C5
n4:logS
n5:271B5CE3-363D-11E5-9242-09173F13E4C5
n6:hasATCCode
n7:C09XA01
n4:H-Bond-Acceptor-Count
n5:271B5CF2-363D-11E5-9242-09173F13E4C5
n4:H-Bond-Donor-Count
n5:271B5CF3-363D-11E5-9242-09173F13E4C5
n4:InChIKey
n5:271B5CED-363D-11E5-9242-09173F13E4C5
n4:Polar-Surface-Area--PSA-
n5:271B5CEE-363D-11E5-9242-09173F13E4C5
n4:Polarizability
n5:271B5CF0-363D-11E5-9242-09173F13E4C5
n4:Refractivity
n5:271B5CEF-363D-11E5-9242-09173F13E4C5
n4:Rotatable-Bond-Count
n5:271B5CF1-363D-11E5-9242-09173F13E4C5
n4:absorption
Absorbed following oral administration.
n4:affectedOrganism
Humans and other mammals
n4:caco2-Permeability
n5:271B5CFD-363D-11E5-9242-09173F13E4C5
n4:casRegistryNumber
126222-34-2
n4:Bioavailability
n5:271B5CF8-363D-11E5-9242-09173F13E4C5
n4:Ghose-Filter
n5:271B5CFA-363D-11E5-9242-09173F13E4C5
n4:MDDR-Like-Rule
n5:271B5CFB-363D-11E5-9242-09173F13E4C5
n4:Number-of-Rings
n5:271B5CF7-363D-11E5-9242-09173F13E4C5
n4:Physiological-Charge
n5:271B5CF6-363D-11E5-9242-09173F13E4C5
n4:Rule-of-Five
n5:271B5CF9-363D-11E5-9242-09173F13E4C5
n4:Traditional-IUPAC-Name
n5:271B5CE7-363D-11E5-9242-09173F13E4C5
n4:pKa--strongest-acidic-
n5:271B5CF4-363D-11E5-9242-09173F13E4C5
n4:pKa--strongest-basic-
n5:271B5CF5-363D-11E5-9242-09173F13E4C5