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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/national-drug-code-directory/
dctermshttp://purl.org/dc/terms/
n15http://linked.opendata.cz/resource/AHFS/
n11http://linked.opendata.cz/resource/drugbank/company/
foafhttp://xmlns.com/foaf/0.1/
n14http://linked.opendata.cz/resource/drugbank/dosage/
n24http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/chemspider/
n27http://bio2rdf.org/drugbank:
n19http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/wikipedia/
n22http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/pharmgkb/
admshttp://www.w3.org/ns/adms#
n16http://www.rxlist.com/cgi/generic/
n7http://linked.opendata.cz/resource/drugbank/patent/
n13http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n20http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/pubchem-compound/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n17http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n10http://www.drugs.com/cdi/
n4http://linked.opendata.cz/resource/drugbank/property/
n26http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/pubchem-substance/
n21http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/kegg-drug/
n25http://linked.opendata.cz/resource/drugbank/drug/DB00209/identifier/drugbank/
xsdhhttp://www.w3.org/2001/XMLSchema#
n6http://linked.opendata.cz/resource/atc/
n5http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00209
rdf:type
n3:Drug
n3:description
Trospium is a urinary antispasmodic. It is sold under the brand name Sanctura in the US, and as Trosec in Canada. [Wikipedia]
n3:dosage
n14:271B5C4F-363D-11E5-9242-09173F13E4C5 n14:271B5C50-363D-11E5-9242-09173F13E4C5 n14:271B5C51-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
20 hours
n3:indication
For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.
n3:manufacturer
n11:271B5C4B-363D-11E5-9242-09173F13E4C5
owl:sameAs
n13:DB00209 n27:DB00209
dcterms:title
Trospium
adms:identifier
n19:Trospium n20:5596 n21:D01103 n22:PA164748976 n23:0023-3513-60 n24:5394 n25:DB00209 n26:46506398
n3:mechanismOfAction
Trospium antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder.
n3:packager
n11:271B5C45-363D-11E5-9242-09173F13E4C5 n11:271B5C46-363D-11E5-9242-09173F13E4C5 n11:271B5C43-363D-11E5-9242-09173F13E4C5 n11:271B5C44-363D-11E5-9242-09173F13E4C5 n11:271B5C47-363D-11E5-9242-09173F13E4C5 n11:271B5C4A-363D-11E5-9242-09173F13E4C5 n11:271B5C48-363D-11E5-9242-09173F13E4C5 n11:271B5C49-363D-11E5-9242-09173F13E4C5
n3:patent
n7:7759359 n7:2537103 n7:7410978
n3:routeOfElimination
After administration of oral 14C-trospium chloride, the majority of the dose (85.2%) was recovered in feces and a smaller amount (5.8% of the dose) was recovered in urine; 60% of the radioactivity excreted in urine was unchanged trospium. The mean renal clearance for trospium (29.07 L/hour) is 4-fold higher than average glomerular filtration rate, indicating that active tubular secretion is a major route of elimination for trospium. SANCTURA ® is metabolized by ester hydrolysis and excreted by the kidneys by a combination of tubular secretion and glomerular filtration.
n3:volumeOfDistribution
* 395 ± 140 L
n5:hasAHFSCode
n15:86-12-00
n3:proteinBinding
50-85%
n3:salt
foaf:page
n10:trospium.html n16:sanctura.htm
n3:IUPAC-Name
n4:271B5C56-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5C5C-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5C5B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5C58-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5C59-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5C5A-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5C54-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5C52-363D-11E5-9242-09173F13E4C5 n4:271B5C55-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5C53-363D-11E5-9242-09173F13E4C5
n5:hasATCCode
n6:G04BD09
n3:H-Bond-Acceptor-Count
n4:271B5C62-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5C63-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5C5D-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5C5E-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5C60-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5C5F-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5C61-363D-11E5-9242-09173F13E4C5
n3:absorption
9.6%
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
10405-02-4
n3:clearance
* Renal cl=29.07 L/hour
n3:containedIn
n17:271B5C4D-363D-11E5-9242-09173F13E4C5 n17:271B5C4E-363D-11E5-9242-09173F13E4C5 n17:271B5C4C-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B5C68-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5C6A-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B5C6B-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5C67-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5C66-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5C69-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5C57-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5C64-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5C65-363D-11E5-9242-09173F13E4C5