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Namespace Prefixes

PrefixIRI
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n8http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00200
rdf:type
n3:Drug
n3:description
Injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. [PubChem]
n3:dosage
n23:271B5958-363D-11E5-9242-09173F13E4C5 n23:271B5959-363D-11E5-9242-09173F13E4C5 n23:271B595A-363D-11E5-9242-09173F13E4C5 n23:271B595B-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# "Link":http://www.medsafe.govt.nz/profs/Datasheet/n/Neocytameninj.htm # Seetharam B, Yammani RR: Cobalamin transport proteins and their cell-surface receptors. Expert Rev Mol Med. 2003 Jun 13;5(18):1-18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14585166
n3:group
approved
n3:halfLife
Approximately 6 days (peak plasma concentration after 8-12 hours from oral administration)
n3:indication
For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.
n3:manufacturer
n7:271B5955-363D-11E5-9242-09173F13E4C5 n7:271B5953-363D-11E5-9242-09173F13E4C5 n7:271B5954-363D-11E5-9242-09173F13E4C5 n7:271B5951-363D-11E5-9242-09173F13E4C5 n7:271B5952-363D-11E5-9242-09173F13E4C5
owl:sameAs
n25:DB00200 n28:DB00200
dcterms:title
Hydroxocobalamin
adms:identifier
n13:D01027 n14:11704-270-01 n15:C08230 n16:27786 n17:DB00200 n18:Hydroxocobalamin n19:PA164768689
n3:mechanismOfAction
Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of these, methylcobalamin and 5-deoxyadenosyl cobalamin, are primarily used by the body. Methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
n3:packager
n7:271B5949-363D-11E5-9242-09173F13E4C5 n7:271B594A-363D-11E5-9242-09173F13E4C5 n7:271B5948-363D-11E5-9242-09173F13E4C5 n7:271B594D-363D-11E5-9242-09173F13E4C5 n7:271B594E-363D-11E5-9242-09173F13E4C5 n7:271B594B-363D-11E5-9242-09173F13E4C5 n7:271B594C-363D-11E5-9242-09173F13E4C5 n7:271B594F-363D-11E5-9242-09173F13E4C5 n7:271B5950-363D-11E5-9242-09173F13E4C5
n3:patent
n6:5834448
n3:routeOfElimination
Each hydroxocobalamin molecule can bind one cyanide ion by substituting it for the hydroxo ligand linked to the trivalent cobalt ion, to form cyanocobalamin, which is then excreted in the urine.
n3:synonym
Hydroxocobalamin Vitamin B-12b OH-Cbl Hydroxycobalamin
n8:hasAHFSCode
n21:88-08-00
n3:mixture
n22:271B5946-363D-11E5-9242-09173F13E4C5 n22:271B5947-363D-11E5-9242-09173F13E4C5 n22:271B5944-363D-11E5-9242-09173F13E4C5 n22:271B5945-363D-11E5-9242-09173F13E4C5 n22:271B5942-363D-11E5-9242-09173F13E4C5 n22:271B5943-363D-11E5-9242-09173F13E4C5 n22:271B5940-363D-11E5-9242-09173F13E4C5 n22:271B5941-363D-11E5-9242-09173F13E4C5 n22:271B593E-363D-11E5-9242-09173F13E4C5 n22:271B593F-363D-11E5-9242-09173F13E4C5 n22:271B593C-363D-11E5-9242-09173F13E4C5 n22:271B593D-363D-11E5-9242-09173F13E4C5
n3:proteinBinding
Very high (90%). Cobalamins are extensively bound to two specific plasma proteins called transcobalamin 1 and 2; 70% to transcobalamin 1, 5% to transcobalamin 2.
n3:synthesisReference
Takayuki Hirayama, Takashi Kiyota, "Process for production of hydroxocobalamin." U.S. Patent US5338418, issued June, 1982.
n26:hasConcept
n27:M0010744
foaf:page
n11:hydroxocobalamin.html n29:cyanokit.htm
n3:IUPAC-Name
n4:271B595F-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5965-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5964-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5961-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5962-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5963-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B595E-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B595C-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B595D-363D-11E5-9242-09173F13E4C5
n8:hasATCCode
n9:B03BA03 n9:V03AB33
n3:InChIKey
n4:271B5966-363D-11E5-9242-09173F13E4C5
n3:absorption
Readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Vitamin B12 is absorbed in the lower half of the ileum.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
13422-51-0
n3:category
n3:containedIn
n20:271B5956-363D-11E5-9242-09173F13E4C5 n20:271B5957-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B596B-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B596D-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B596E-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B596A-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5969-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B596C-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5960-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5967-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5968-363D-11E5-9242-09173F13E4C5