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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n25http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/chemspider/
dctermshttp://purl.org/dc/terms/
n22http://linked.opendata.cz/resource/mesh/concept/
n8http://linked.opendata.cz/resource/drugbank/company/
n24http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/chebi/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/pharmgkb/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/wikipedia/
n7http://bio2rdf.org/drugbank:
n19http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/kegg-compound/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/pdb/
admshttp://www.w3.org/ns/adms#
n14http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/pubchem-compound/
n6http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/resource/drugbank/medicinal-product/
n15http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/kegg-drug/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/pubchem-substance/
owlhttp://www.w3.org/2002/07/owl#
n18http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/iuphar/
n20http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/drugbank/
n21http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00172/identifier/guide-to-pharmacology/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB00172
rdf:type
n3:Drug
n3:description
A non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. [PubChem]
n3:group
nutraceutical approved
n3:indication
L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.
owl:sameAs
n6:DB00172 n7:DB00172
dcterms:title
L-Proline
adms:identifier
n10:L-Proline n11:46506858 n13:PA451125 n14:145742 n15:D00035 n16:PRO n18:3314 n19:C00148 n20:DB00172 n23:3314 n24:17203 n25:128566
n3:mechanismOfAction
Glycogenic, by L-Proline oxidase in the kidney, it is ring-opened and is oxidized to form L-Glutamic acid. L-Ornithine and L-Glutamic acid are converted to L-Proline via L-Glutamic acid-gamma-semialdehyde. It is contained abundantly in collagen, and is intimately involved in the function of arthrosis and chordae.
n3:packager
n8:271B508A-363D-11E5-9242-09173F13E4C5
n3:synonym
PROLINE 2-Pyrrolidinecarboxylic acid L-(-)-Proline Prolina (−)-proline L-Prolin L-alpha-pyrrolidinecarboxylic acid P Prolinum (2S)-Pyrrolidine-2-carboxylic acid L-pyrrolidine-2-carboxylic acid (−)-(S)-proline (−)-2-pyrrolidinecarboxylic acid (-)-Proline (S)-2-Pyrrolidinecarboxylic acid (-)-(S)-Proline (-)-2-Pyrrolidinecarboxylic acid (S)-Pyrrolidine-2-carboxylic acid L-Proline L-α-pyrrolidinecarboxylic acid (S)-2-Carboxypyrrolidine
n3:synthesisReference
Richard I. Leavitt, "L-Proline production from algae." U.S. Patent US4383039, issued October, 1968.
n21:hasConcept
n22:M0017693
n3:IUPAC-Name
n4:271B5090-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5096-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5095-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5092-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5093-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5094-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B508E-363D-11E5-9242-09173F13E4C5 n4:271B50A6-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B508C-363D-11E5-9242-09173F13E4C5 n4:271B508F-363D-11E5-9242-09173F13E4C5 n4:271B50A8-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B508D-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B509C-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B509D-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5097-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5098-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B509A-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5099-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B509B-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
147-85-3
n3:category
n3:containedIn
n12:271B508B-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B50A2-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B50A4-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B50A5-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B50A7-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B50A1-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B50A0-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B50A3-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5091-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B509E-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B509F-363D-11E5-9242-09173F13E4C5