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Namespace Prefixes

PrefixIRI
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n7http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00158
rdf:type
n3:Drug
n3:description
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]
n3:dosage
n5:271B4DD5-363D-11E5-9242-09173F13E4C5 n5:271B4DD4-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Kamen B: Folate and antifolate pharmacology. Semin Oncol. 1997 Oct;24(5 Suppl 18):S18-30-S18-39. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9420019 # Fenech M, Aitken C, Rinaldi J: Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 1998 Jul;19(7):1163-71. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9683174 # Zittoun J: [Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism] Rev Prat. 1993 Jun 1;43(11):1358-63. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8235383 # Alaimo K, McDowell MA, Briefel RR, Bischof AM, Caughman CR, Loria CM, Johnson CL: Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988-91. Adv Data. 1994 Nov 14;(258):1-28. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10138938 # Raiten DJ, Fisher KD: Assessment of folate methodology used in the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). J Nutr. 1995 May;125(5):1371S-1398S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7738698
n3:group
nutraceutical approved
n3:indication
For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood.
n3:manufacturer
n6:271B4DAC-363D-11E5-9242-09173F13E4C5 n6:271B4DAD-363D-11E5-9242-09173F13E4C5 n6:271B4DAA-363D-11E5-9242-09173F13E4C5 n6:271B4DAB-363D-11E5-9242-09173F13E4C5 n6:271B4DB0-363D-11E5-9242-09173F13E4C5 n6:271B4DB1-363D-11E5-9242-09173F13E4C5 n6:271B4DAE-363D-11E5-9242-09173F13E4C5 n6:271B4DAF-363D-11E5-9242-09173F13E4C5 n6:271B4DA8-363D-11E5-9242-09173F13E4C5 n6:271B4DA9-363D-11E5-9242-09173F13E4C5 n6:271B4DBC-363D-11E5-9242-09173F13E4C5 n6:271B4DBD-363D-11E5-9242-09173F13E4C5 n6:271B4DBA-363D-11E5-9242-09173F13E4C5 n6:271B4DBB-363D-11E5-9242-09173F13E4C5 n6:271B4DC0-363D-11E5-9242-09173F13E4C5 n6:271B4DC1-363D-11E5-9242-09173F13E4C5 n6:271B4DBE-363D-11E5-9242-09173F13E4C5 n6:271B4DBF-363D-11E5-9242-09173F13E4C5 n6:271B4DB4-363D-11E5-9242-09173F13E4C5 n6:271B4DB5-363D-11E5-9242-09173F13E4C5 n6:271B4DB2-363D-11E5-9242-09173F13E4C5 n6:271B4DB3-363D-11E5-9242-09173F13E4C5 n6:271B4DB8-363D-11E5-9242-09173F13E4C5 n6:271B4DB9-363D-11E5-9242-09173F13E4C5 n6:271B4DB6-363D-11E5-9242-09173F13E4C5 n6:271B4DB7-363D-11E5-9242-09173F13E4C5 n6:271B4DC4-363D-11E5-9242-09173F13E4C5 n6:271B4DC5-363D-11E5-9242-09173F13E4C5 n6:271B4DC2-363D-11E5-9242-09173F13E4C5 n6:271B4DC3-363D-11E5-9242-09173F13E4C5 n6:271B4DC8-363D-11E5-9242-09173F13E4C5 n6:271B4DC9-363D-11E5-9242-09173F13E4C5 n6:271B4DC6-363D-11E5-9242-09173F13E4C5 n6:271B4DC7-363D-11E5-9242-09173F13E4C5
owl:sameAs
n13:DB00158 n31:DB00158
dcterms:title
Folic Acid
adms:identifier
n15:Folic_Acid n21:46508092 n22:C00504 n23:D00070 n24:5815 n25:DB00158 n26:PA449692 n27:6037 n28:42291-533-10 n29:FOL n30:27470
n3:mechanismOfAction
Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
n3:packager
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n3:routeOfElimination
Folic Acid is metabolized in the liver to 7, 8-dihydrofolic acid and eventually to 5,6,7,8-tetrahydrofolic acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Folic Acid is also excreted in the milk of lactating mothers.
n3:synonym
Vitamin B9 Pteroylglutamic acid Pteroyl-L-glutamic acid Folsaeure Pteroyl-L-glutamate Folacin Folic acid Folate PteGlu N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid Pteroyl-L-monoglutamic acid Vitamin M PGA N-Pteroyl-L-glutamic acid Vitamin Bc
n3:toxicity
IPR-MUS LD<sub>50</sub> 85 mg/kg,IVN-GPG LD<sub>50</sub> 120 mg/kg, IVN-MUS LD<sub>50</sub> 239 mg/kg, IVN-RAT LD<sub>50</sub> 500 mg/kg, IVN-RBT LD<sub>50</sub> 410 mg/kg
n7:hasAHFSCode
n20:88-08-00
n3:proteinBinding
Very high to plasma protein
n3:synthesisReference
Carroll G. Temple, Jr., Robert D. Elliott, Jerry D. Rose, John A. Montgomery, "Preparation of tetrahydrofolic acid from folic acid." U.S. Patent US4206307, issued April, 1956.
n17:hasConcept
n18:M0008658
foaf:page
n10:fol_0110.shtml n19:folic_acid.html
n3:IUPAC-Name
n4:271B4DDA-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4DE0-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4DDF-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4DDC-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4DDD-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4DDE-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4DF0-363D-11E5-9242-09173F13E4C5 n4:271B4DD8-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4DD9-363D-11E5-9242-09173F13E4C5 n4:271B4DD6-363D-11E5-9242-09173F13E4C5 n4:271B4DF2-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4DD7-363D-11E5-9242-09173F13E4C5
n7:hasATCCode
n8:B03BB01
n3:H-Bond-Acceptor-Count
n4:271B4DE6-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4DE7-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4DE1-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4DE2-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4DE4-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4DE3-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4DE5-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
59-30-3
n3:category
n3:containedIn
n11:271B4DD2-363D-11E5-9242-09173F13E4C5 n11:271B4DD3-363D-11E5-9242-09173F13E4C5 n11:271B4DD0-363D-11E5-9242-09173F13E4C5 n11:271B4DD1-363D-11E5-9242-09173F13E4C5 n11:271B4DCE-363D-11E5-9242-09173F13E4C5 n11:271B4DCF-363D-11E5-9242-09173F13E4C5 n11:271B4DCC-363D-11E5-9242-09173F13E4C5 n11:271B4DCD-363D-11E5-9242-09173F13E4C5 n11:271B4DCA-363D-11E5-9242-09173F13E4C5 n11:271B4DCB-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B4DEC-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4DEE-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4DEF-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B4DF1-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4DEB-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4DEA-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4DED-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4DDB-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4DE8-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4DE9-363D-11E5-9242-09173F13E4C5