This HTML5 document contains 94 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n17http://linked.opendata.cz/resource/AHFS/
n10http://linked.opendata.cz/resource/mesh/concept/
n22http://linked.opendata.cz/resource/drugbank/company/
foafhttp://xmlns.com/foaf/0.1/
n11http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/chemspider/
n14http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/chebi/
n21http://bio2rdf.org/drugbank:
n4http://www.drugs.com/cons/
admshttp://www.w3.org/ns/adms#
n26http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/pharmgkb/
n19http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/wikipedia/
n24http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n29http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/pdb/
n8http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/kegg-compound/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n18http://linked.opendata.cz/resource/drugbank/medicinal-product/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/bindingdb/
n9http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n23http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/
n27http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/pubchem-compound/
n5http://linked.opendata.cz/ontology/drugbank/
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n28http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/kegg-drug/
n25http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/pubchem-substance/
n12http://linked.opendata.cz/resource/drugbank/drug/DB00121/identifier/drugbank/
n30http://linked.opendata.cz/resource/atc/
n16http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00121
rdf:type
n5:Drug
n5:description
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. [PubChem]
n5:generalReferences
# Holmberg A, Blomstergren A, Nord O, Lukacs M, Lundeberg J, Uhlen M: The biotin-streptavidin interaction can be reversibly broken using water at elevated temperatures. Electrophoresis. 2005 Feb;26(3):501-10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15690449
n5:group
approved nutraceutical
n5:indication
For nutritional supplementation, also for treating dietary shortage or imbalance.
owl:sameAs
n21:DB00121 n24:DB00121
dcterms:title
Biotin
adms:identifier
n8:C00120 n11:149962 n12:DB00121 n13:12 n14:15956 n19:Biotin n25:46508694 n26:PA448625 n27:171548 n28:D00029 n29:BTN
n5:mechanismOfAction
Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.
n5:packager
n22:271B4753-363D-11E5-9242-09173F13E4C5 n22:271B4754-363D-11E5-9242-09173F13E4C5 n22:271B4751-363D-11E5-9242-09173F13E4C5 n22:271B4752-363D-11E5-9242-09173F13E4C5 n22:271B474C-363D-11E5-9242-09173F13E4C5 n22:271B474F-363D-11E5-9242-09173F13E4C5 n22:271B4750-363D-11E5-9242-09173F13E4C5 n22:271B474D-363D-11E5-9242-09173F13E4C5 n22:271B474E-363D-11E5-9242-09173F13E4C5
n5:synonym
Vitamin B7 (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid Biotinum Biotine D-Biotin Biotin Vitamin H D-(+)-Biotin 5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoic acid (3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid Coenzyme R cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid D(+)-Biotin cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid Biotina cis-Tetrahydro-2-oxothieno(3,4-D)imidazoline-4-valeric acid
n5:toxicity
Prolonged skin contact may cause irritation.
n16:hasAHFSCode
n17:88-08-00
n5:synthesisReference
Takayoshi Mitsunaga, Kiyoto Chinushi, Tadashi Umezu, "Water-soluble biotin-containing preparation." U.S. Patent US4277488, issued May, 1940.
n9:hasConcept
n10:M0002565
foaf:page
n4:biotin.html n23:bio_0035.shtml
n5:IUPAC-Name
n6:271B4761-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B4767-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B4766-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B4763-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B4764-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B4765-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B475F-363D-11E5-9242-09173F13E4C5 n6:271B4777-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B475D-363D-11E5-9242-09173F13E4C5 n6:271B4760-363D-11E5-9242-09173F13E4C5 n6:271B4779-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B475E-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n30:A11HA05
n5:H-Bond-Acceptor-Count
n6:271B476D-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B476E-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B4768-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B4769-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B476B-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B476A-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B476C-363D-11E5-9242-09173F13E4C5
n5:absorption
Systemic - approximately 50%
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
58-85-5
n5:category
n5:containedIn
n18:271B4757-363D-11E5-9242-09173F13E4C5 n18:271B4758-363D-11E5-9242-09173F13E4C5 n18:271B4755-363D-11E5-9242-09173F13E4C5 n18:271B4756-363D-11E5-9242-09173F13E4C5 n18:271B475B-363D-11E5-9242-09173F13E4C5 n18:271B475C-363D-11E5-9242-09173F13E4C5 n18:271B4759-363D-11E5-9242-09173F13E4C5 n18:271B475A-363D-11E5-9242-09173F13E4C5
n5:Bioavailability
n6:271B4773-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B4775-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B4776-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n6:271B4778-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B4772-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B4771-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B4774-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B4762-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n6:271B476F-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B4770-363D-11E5-9242-09173F13E4C5