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Namespace Prefixes

PrefixIRI
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n14http://linked.opendata.cz/resource/drugbank/company/
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n5http://linked.opendata.cz/resource/mesh/concept/
n21http://linked.opendata.cz/resource/drugbank/drug/DB00111/identifier/wikipedia/
n20http://linked.opendata.cz/resource/drugbank/drug/DB00111/identifier/pharmgkb/
n13http://bio2rdf.org/drugbank:
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n3http://linked.opendata.cz/ontology/drugbank/
n23http://www.drugs.com/cdi/
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/resource/atc/
n16http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00111
rdf:type
n3:Drug
n3:description
Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining regions of a murine anti-Tac antibody.
n3:group
approved investigational
n3:halfLife
11-38 days
n3:indication
Zenapax is a humanized monoclonal antibody used for prevention of renal transplant rejection
owl:sameAs
n13:DB00111 n22:DB00111
dcterms:title
Daclizumab
adms:identifier
n9:DB00111 n15:P01857 n19:J00228 n20:PA164764446 n21:Daclizumab
n3:mechanismOfAction
Zenepax binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes.
n3:packager
n14:271B4602-363D-11E5-9242-09173F13E4C5 n14:271B4603-363D-11E5-9242-09173F13E4C5
n3:synonym
Anti-IL-2 Ig gamma-1 chain C region Humanized antiCD25
n16:hasAHFSCode
n18:92-00-00
n4:hasConcept
n5:M0252703
foaf:page
n11:zenapax.htm n23:daclizumab.html
n3:Molecular-Formula
n6:271B4608-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n6:271B4607-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n17:L04AC01
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
152923-56-3
n3:category
n3:Hydrophobicity
n6:271B4605-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n6:271B4606-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n6:271B4604-363D-11E5-9242-09173F13E4C5