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Namespace Prefixes

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Statements

Subject Item
n2:DB00094
rdf:type
n3:Drug
n3:description
Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Urofollitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).
n3:dosage
n16:271B44E1-363D-11E5-9242-09173F13E4C5 n16:271B44E2-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Goa KL, Wagstaff AJ: Follitropin alpha in infertility: a review. BioDrugs. 1998 Mar;9(3):235-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18020563 #Lexicomp. Urofollitropin. N.p., 2014. Web. 11 Nov. 2014. http://online.lexi.com.login.ezproxy.library.ualberta.ca/lco/action/doc/retrieve/docid/patch_f/797#f_pharmacology-and-pharmacokinetics
n3:group
approved
n3:halfLife
Circulation half life of 3-4 hours, elimination half life of 35-40 hours
n3:indication
For treatment of female infertility
n3:manufacturer
n4:271B44DE-363D-11E5-9242-09173F13E4C5 n4:271B44DD-363D-11E5-9242-09173F13E4C5
owl:sameAs
n18:DB00094 n27:DB00094
dcterms:title
Urofollitropin
adms:identifier
n8:PA451835 n9:P01225 n10:M16647 n11:55566-8505-2 n12:DB00094 n21:Urofollitropin
n3:mechanismOfAction
FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
n3:packager
n4:271B44D8-363D-11E5-9242-09173F13E4C5 n4:271B44D9-363D-11E5-9242-09173F13E4C5 n4:271B44D6-363D-11E5-9242-09173F13E4C5 n4:271B44D7-363D-11E5-9242-09173F13E4C5 n4:271B44DC-363D-11E5-9242-09173F13E4C5 n4:271B44DA-363D-11E5-9242-09173F13E4C5 n4:271B44DB-363D-11E5-9242-09173F13E4C5 n4:271B44D4-363D-11E5-9242-09173F13E4C5 n4:271B44D5-363D-11E5-9242-09173F13E4C5
n3:patent
n14:5767067
n3:routeOfElimination
Via liver and kidneys
n3:synonym
Urofollitrophin FSH-beta Follitropin beta chain precursor Follicle-stimulating hormone beta subunit FSH-B Follicle Stimulating Hormone FSH
n3:volumeOfDistribution
Time to peak in plasma: IM: 17 hours (single dose), 11 hours (multiple doses) SubQ: 21 hours (single dose), 10 hours (multiple doses)
n5:hasAHFSCode
n6:68-18-00
n19:hasConcept
n20:M0013388
foaf:page
n24:urofollitropin-purified.html n25:urofollitropin.htm
n3:Molecular-Formula
n15:271B44E7-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n15:271B44E6-363D-11E5-9242-09173F13E4C5
n5:hasATCCode
n26:G03GA04
n3:absorption
74%
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
146479-72-3
n3:category
n3:containedIn
n22:271B44E0-363D-11E5-9242-09173F13E4C5 n22:271B44DF-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n15:271B44E4-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n15:271B44E5-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n15:271B44E3-363D-11E5-9242-09173F13E4C5