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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n12http://linked.opendata.cz/resource/AHFS/
n18http://linked.opendata.cz/resource/drugbank/company/
n19http://linked.opendata.cz/resource/drugbank/dosage/
n13http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/wikipedia/
n5http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/pharmgkb/
n7http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n16http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n9http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/kegg-drug/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n17http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/drugbank/
n14http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n8http://linked.opendata.cz/resource/drugbank/property/
n10http://linked.opendata.cz/resource/drugbank/drug/DB00075/identifier/national-drug-code-directory/
xsdhhttp://www.w3.org/2001/XMLSchema#
n20http://linked.opendata.cz/resource/atc/
n11http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00075
rdf:type
n3:Drug
n3:description
Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
n3:dosage
n19:271B4384-363D-11E5-9242-09173F13E4C5
n3:group
approved investigational
n3:halfLife
0.8 hours (mammalian reticulocytes, in vitro)
n3:indication
For treatment of organ transplant recipients, prevention of organ rejection
owl:sameAs
n7:DB00075 n16:DB00075
dcterms:title
Muromonab
adms:identifier
n5:PA164743097 n9:D05092 n10:59676-101-01 n13:Muromonab n17:DB00075
n3:mechanismOfAction
Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
n3:packager
n18:271B4382-363D-11E5-9242-09173F13E4C5
n3:synonym
Muromonab-CD3 Anti-CD3
n11:hasAHFSCode
n12:92-00-00
n3:Molecular-Formula
n8:271B4389-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n8:271B4388-363D-11E5-9242-09173F13E4C5
n11:hasATCCode
n20:L04AA02
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
140608-64-6
n3:category
n3:containedIn
n14:271B4383-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n8:271B4386-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n8:271B4387-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n8:271B4385-363D-11E5-9242-09173F13E4C5