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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00071/identifier/pharmgkb/
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n5http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
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n14http://linked.opendata.cz/resource/drugbank/drug/DB00071/identifier/uniprotkb/

Statements

Subject Item
n2:DB00071
rdf:type
n3:Drug
n3:description
Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.
n3:group
approved
n3:indication
For the treatment of type I and II diabetes mellitus.
n3:manufacturer
n10:271B4358-363D-11E5-9242-09173F13E4C5 n10:271B4357-363D-11E5-9242-09173F13E4C5
owl:sameAs
n5:DB00071 n11:DB00071
dcterms:title
Insulin, porcine
adms:identifier
n13:AY137503 n14:Q8HXV2 n15:DB00071 n16:PA164781053
n3:mechanismOfAction
Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism.
n3:synthesisReference
Bruce H. Frank, "Process for producing an insulin precursor." U.S. Patent US4430266, issued November, 1974.
n7:hasConcept
n8:M0423949
n3:Molecular-Formula
n6:271B435D-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n6:271B435C-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n6:271B4359-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9004-14-2
n3:category
n3:Hydrophobicity
n6:271B435A-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n6:271B435B-363D-11E5-9242-09173F13E4C5