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Statements

Subject Item
n2:DB00033
rdf:type
n3:Drug
n3:description
Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
n3:dosage
n4:271B40AF-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Kantoch M, Dobrowolska H, Jarzabek Z, Jankowski M, Sadowski W, Janicki P: [Distribution and characteristics of Poliovirus strains circulating in Poland in 1968-1972. Genetic variation of strains isolated in various secretion periods and clones isolated from vaccines] Med Dosw Mikrobiol. 1975;27(4):353-63. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/55526 # Ormas P, Pompa G, Beretta C, Faustini R: [The effects of some polypeptides on the systemic blood pressure of sheep (author's transl)] Folia Vet Lat. 1975 Jan-Mar;5(1):45-54. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3458 # Selitrennikoff CP, Sonneborn DR: Alkaline phosphatase of Blastocladiella emersonii: partial purification and characterization. J Bacteriol. 1977 Apr;130(1):249-56. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15978 # Gray PW, Goeddel DV: Structure of the human immune interferon gene. Nature. 1982 Aug 26;298(5877):859-63. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6180322 # Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE: Three-dimensional structure of recombinant human interferon-gamma. Science. 1991 May 3;252(5006):698-702. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1902591 # Ikeda H, Old LJ, Schreiber RD: The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 2002 Apr;13(2):95-109. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11900986 # Chesler DA, Reiss CS: The role of IFN-gamma in immune responses to viral infections of the central nervous system. Cytokine Growth Factor Rev. 2002 Dec;13(6):441-54. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12401479 # Dessein A, Kouriba B, Eboumbou C, Dessein H, Argiro L, Marquet S, Elwali NE, Rodrigues V, Li Y, Doumbo O, Chevillard C: Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis. Immunol Rev. 2004 Oct;201:180-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15361241 # Joseph AM, Kumar M, Mitra D: Nef: "necessary and enforcing factor" in HIV infection. Curr HIV Res. 2005 Jan;3(1):87-94. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15638726 # Copeland KF: Modulation of HIV-1 transcription by cytokines and chemokines. Mini Rev Med Chem. 2005 Dec;5(12):1093-101. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16375755 # Schroder K, Hertzog PJ, Ravasi T, Hume DA: Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004 Feb;75(2):163-89. Epub 2003 Oct 2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14525967
n3:group
investigational approved
n3:indication
Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.
owl:sameAs
n9:DB00033 n10:DB00033
dcterms:title
Interferon gamma-1b
adms:identifier
n12:PA164746386 n13:Interferon_gamma-1b n16:P01579 n17:DB00033 n20:X13274
n3:mechanismOfAction
Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
n3:packager
n6:271B40AD-363D-11E5-9242-09173F13E4C5
n3:patent
n14:6936695 n14:6936694
n3:synonym
Immune interferon Interferon gamma precursor IFN-gamma
n3:synthesisReference
Irwin A. Braude, "Production of human IFN-gamma (immune) interferon." U.S. Patent US4376821, issued December, 1975.
n18:hasConcept
n19:M0329535
foaf:page
n22:interferon-gamma-1b.html
n3:Molecular-Formula
n5:271B40B4-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B40B3-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
82115-62-6
n3:category
n3:containedIn
n15:271B40AE-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n5:271B40B1-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n5:271B40B2-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n5:271B40B0-363D-11E5-9242-09173F13E4C5