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Namespace Prefixes

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Statements

Subject Item
n2:DB00020
rdf:type
n8:Drug
n8:description
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
n8:dosage
n18:271B3FBE-363D-11E5-9242-09173F13E4C5 n18:271B3FBF-363D-11E5-9242-09173F13E4C5
n8:group
investigational approved
n8:indication
For the treatment of cancer and bone marrow transplant
owl:sameAs
n13:DB00020 n22:DB00020
dcterms:title
Sargramostim
adms:identifier
n4:M13207 n5:50419-002-33 n6:DB00020 n7:P04141 n25:Sargramostim n26:PA164748631
n8:mechanismOfAction
Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
n8:packager
n9:271B3FBB-363D-11E5-9242-09173F13E4C5 n9:271B3FB9-363D-11E5-9242-09173F13E4C5 n9:271B3FBA-363D-11E5-9242-09173F13E4C5 n9:271B3FB7-363D-11E5-9242-09173F13E4C5 n9:271B3FB8-363D-11E5-9242-09173F13E4C5 n9:271B3FB6-363D-11E5-9242-09173F13E4C5
n8:patent
n19:1341150
n8:synonym
GM-CSF
n8:synthesisReference
Kaname Sugimoto, "Process for the production of human colony-stimulating factor." U.S. Patent US4621050, issued May, 1983.
n14:hasConcept
n15:M0216684
foaf:page
n11:sargramostim.html n21:sargramostim.htm
n8:Molecular-Formula
n24:271B3FC2-363D-11E5-9242-09173F13E4C5
n8:Molecular-Weight
n24:271B3FC1-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n17:L03AA09
n8:affectedOrganism
Humans and other mammals
n8:casRegistryNumber
83869-56-1
n8:category
n8:clearance
* 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)] * 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)] * 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)] * 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]
n8:containedIn
n23:271B3FBD-363D-11E5-9242-09173F13E4C5 n23:271B3FBC-363D-11E5-9242-09173F13E4C5
n8:Isoelectric-Point
n24:271B3FC0-363D-11E5-9242-09173F13E4C5