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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB00015
rdf:type
n3:Drug
n3:description
Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase - kringle-1, finger, and epidermal growth factor (EGF).
n3:dosage
n10:271B3F5E-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction
owl:sameAs
n15:DB00015 n20:DB00015
dcterms:title
Reteplase
adms:identifier
n6:DB00015 n11:PA164743728 n16:P00750 n17:L00153 n18:24477-041-02 n25:Reteplase
n3:mechanismOfAction
Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
n3:packager
n24:271B3F5A-363D-11E5-9242-09173F13E4C5 n24:271B3F5B-363D-11E5-9242-09173F13E4C5 n24:271B3F5C-363D-11E5-9242-09173F13E4C5
n3:patent
n26:2107476
n3:synonym
Tissue-type plasminogen activator precursor tPA t-plasminogen activator t- PA
n8:hasConcept
n9:M0232706
foaf:page
n13:reteplase.html n23:reteplase.htm
n3:Molecular-Formula
n4:271B3F63-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3F62-363D-11E5-9242-09173F13E4C5
n21:hasATCCode
n22:B01AD07
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
133652-38-7
n3:category
n3:containedIn
n7:271B3F5D-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n4:271B3F60-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n4:271B3F61-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B3F5F-363D-11E5-9242-09173F13E4C5