This HTML5 document contains 61 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n11http://linked.opendata.cz/resource/AHFS/
n22http://linked.opendata.cz/resource/drugbank/company/
n26http://linked.opendata.cz/resource/mesh/concept/
foafhttp://xmlns.com/foaf/0.1/
n6http://linked.opendata.cz/resource/drugbank/dosage/
n19http://bio2rdf.org/drugbank:
n15http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/uniprotkb/
n16http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/genbank/
admshttp://www.w3.org/ns/adms#
n7http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/wikipedia/
n9http://www.rxlist.com/cgi/generic/
n5http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/pharmgkb/
n12http://linked.opendata.cz/resource/drugbank/patent/
n20http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n21http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n25http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n24http://www.drugs.com/cdi/
n13http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/resource/drugbank/drug/DB00012/identifier/drugbank/
n23http://linked.opendata.cz/resource/atc/
n10http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00012
rdf:type
n3:Drug
n3:description
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
n3:dosage
n6:271B3F25-363D-11E5-9242-09173F13E4C5 n6:271B3F26-363D-11E5-9242-09173F13E4C5 n6:271B3F27-363D-11E5-9242-09173F13E4C5 n6:271B3F28-363D-11E5-9242-09173F13E4C5 n6:271B3F29-363D-11E5-9242-09173F13E4C5 n6:271B3F1B-363D-11E5-9242-09173F13E4C5 n6:271B3F1E-363D-11E5-9242-09173F13E4C5 n6:271B3F1F-363D-11E5-9242-09173F13E4C5 n6:271B3F20-363D-11E5-9242-09173F13E4C5 n6:271B3F21-363D-11E5-9242-09173F13E4C5 n6:271B3F1C-363D-11E5-9242-09173F13E4C5 n6:271B3F1D-363D-11E5-9242-09173F13E4C5 n6:271B3F22-363D-11E5-9242-09173F13E4C5 n6:271B3F23-363D-11E5-9242-09173F13E4C5 n6:271B3F24-363D-11E5-9242-09173F13E4C5
n3:group
approved investigational
n3:indication
For the treatment of anemia (from renal transplants or certain HIV treatment)
n3:manufacturer
n22:271B3F0E-363D-11E5-9242-09173F13E4C5
owl:sameAs
n19:DB00012 n20:DB00012
dcterms:title
Darbepoetin alfa
adms:identifier
n5:PA164743138 n7:Darbepoetin_alfa n15:P01588 n16:X02158 n17:DB00012
n3:mechanismOfAction
Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
n3:packager
n22:271B3F0C-363D-11E5-9242-09173F13E4C5 n22:271B3F0D-363D-11E5-9242-09173F13E4C5
n3:patent
n12:2147124 n12:2165694
n3:synonym
Erythropoietin precursor Epoetin
n10:hasAHFSCode
n11:20-16-00
n25:hasConcept
n26:M0374902
foaf:page
n9:aranesp.htm n24:darbepoetin-alfa-albumin.html
n3:Molecular-Formula
n13:271B3F2E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n13:271B3F2D-363D-11E5-9242-09173F13E4C5
n10:hasATCCode
n23:B03XA02
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
11096-26-7
n3:category
n3:containedIn
n21:271B3F0F-363D-11E5-9242-09173F13E4C5 n21:271B3F10-363D-11E5-9242-09173F13E4C5 n21:271B3F13-363D-11E5-9242-09173F13E4C5 n21:271B3F14-363D-11E5-9242-09173F13E4C5 n21:271B3F11-363D-11E5-9242-09173F13E4C5 n21:271B3F12-363D-11E5-9242-09173F13E4C5 n21:271B3F17-363D-11E5-9242-09173F13E4C5 n21:271B3F18-363D-11E5-9242-09173F13E4C5 n21:271B3F15-363D-11E5-9242-09173F13E4C5 n21:271B3F16-363D-11E5-9242-09173F13E4C5 n21:271B3F19-363D-11E5-9242-09173F13E4C5 n21:271B3F1A-363D-11E5-9242-09173F13E4C5
n3:Hydrophobicity
n13:271B3F2B-363D-11E5-9242-09173F13E4C5
n3:Isoelectric-Point
n13:271B3F2C-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n13:271B3F2A-363D-11E5-9242-09173F13E4C5