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Statements

Subject Item
n2:RIV%2F86652036%3A_____%2F11%3A00369494%21RIV12-AV0-86652036
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Succinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies. Succinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies.
dcterms:title
Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death
skos:prefLabel
Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death
skos:notation
RIV/86652036:_____/11:00369494!RIV12-AV0-86652036
n14:predkladatel
n15:ico%3A86652036
n5:aktivita
n10:Z
n5:aktivity
Z(AV0Z50520701)
n5:cisloPeriodika
11
n5:dodaniDat
n11:2012
n5:domaciTvurceVysledku
n7:4589874
n5:druhVysledku
n17:J
n5:duvernostUdaju
n12:S
n5:entitaPredkladatele
n18:predkladatel
n5:idSjednocenehoVysledku
204853
n5:idVysledku
RIV/86652036:_____/11:00369494
n5:jazykVysledku
n19:eng
n5:klicovaSlova
Mitocans; SDH/Complex II; mitochondrial ROS production
n5:klicoveSlovo
n9:SDH%2FComplex%20II n9:Mitocans n9:mitochondrial%20ROS%20production
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[670CAF776BB2]
n5:nazevZdroje
Pharmaceutical Research
n5:obor
n13:CE
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
4
n5:rokUplatneniVysledku
n11:2011
n5:svazekPeriodika
28
n5:tvurceVysledku
Rodriguez-Enriquez, S. Ralph, S. J. Neužil, Jiří Moreno-Sanchez, R.
n5:wos
000295697700006
n5:zamer
n8:AV0Z50520701
s:issn
0724-8741
s:numberOfPages
35
n16:doi
10.1007/s11095-011-0566-7