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Statements

Subject Item
n2:RIV%2F86652036%3A_____%2F10%3A00349311%21RIV11-GA0-86652036
rdf:type
n12:Vysledek skos:Concept
dcterms:description
We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1beta mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions. We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1beta mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions.
dcterms:title
Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats
skos:prefLabel
Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats
skos:notation
RIV/86652036:_____/10:00349311!RIV11-GA0-86652036
n3:aktivita
n8:P n8:Z
n3:aktivity
P(GA305/06/0427), P(GAP303/10/1368), Z(AV0Z40550506), Z(AV0Z50520701), Z(MSM0021620816)
n3:cisloPeriodika
ID 398026
n3:dodaniDat
n4:2011
n3:domaciTvurceVysledku
n9:3534871
n3:druhVysledku
n11:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
255983
n3:idVysledku
RIV/86652036:_____/10:00349311
n3:jazykVysledku
n17:eng
n3:klicovaSlova
adjuvant arthritis; feeding
n3:klicoveSlovo
n6:feeding n6:adjuvant%20arthritis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[B95A62755217]
n3:nazevZdroje
Mediators of Inflammation
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n15:GAP303%2F10%2F1368 n15:GA305%2F06%2F0427
n3:rokUplatneniVysledku
n4:2010
n3:svazekPeriodika
-
n3:tvurceVysledku
Železná, Blanka Stofková, A. Kiss, A. Skurlová, M. Uličná, O. Romžová, Marianna Jurcovicová, J.
n3:wos
000283184700001
n3:zamer
n13:MSM0021620816 n13:AV0Z40550506 n13:AV0Z50520701
s:issn
0962-9351
s:numberOfPages
12