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Statements

Subject Item
n2:RIV%2F86652036%3A_____%2F08%3A00325125%21RIV09-AV0-86652036
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The role of the death-associated protein Daxx in modulation of apoptosis induced in cardiac myocytes by oxidative stress was studied. Exposure of cardiomyocyte-like cells to oxidative stress or simulated hypoxia increased the level of accumulated ROS and apoptosis. Under conditions of sub-apoptotic stimulation of cardiac myocytes, there was no increase in the level of the Daxx protein, but it translocated from the nucleus to the cytoplasm. Daxx overexpression protected the cells from apoptosis, while they were sensitised to cell death following its down-regulation by siRNA. Lowering the level of the Daxx protein sensitised cardiac myocytes to spontaneous apoptosis, suggesting that the protein may also have a prosurvival role under physiological conditions. Finally, it was shown that DJ-1, a protein suggested previously to sequester Daxx in the nucleus under conditions of oxidative stress preventing thus its cytosolic translocation, was localised in the cytoplasm of cardiac myocytes The role of the death-associated protein Daxx in modulation of apoptosis induced in cardiac myocytes by oxidative stress was studied. Exposure of cardiomyocyte-like cells to oxidative stress or simulated hypoxia increased the level of accumulated ROS and apoptosis. Under conditions of sub-apoptotic stimulation of cardiac myocytes, there was no increase in the level of the Daxx protein, but it translocated from the nucleus to the cytoplasm. Daxx overexpression protected the cells from apoptosis, while they were sensitised to cell death following its down-regulation by siRNA. Lowering the level of the Daxx protein sensitised cardiac myocytes to spontaneous apoptosis, suggesting that the protein may also have a prosurvival role under physiological conditions. Finally, it was shown that DJ-1, a protein suggested previously to sequester Daxx in the nucleus under conditions of oxidative stress preventing thus its cytosolic translocation, was localised in the cytoplasm of cardiac myocytes Byla studována úloha proteinu Daxx v modulaci apoptózy indukované v kardiomyocytech oxidativním stresem. Vystavení buněk podobných kardiomyocytům oxidativnímu stresu nebo simulované hypoxii zvýšilo hladinu akumulovaných ROS a apoptózu. Za podmínek subapoptotické stimulace kardiomyocytů nebyl pozorován žádný vzestup hladiny Daxx proteinu, ale změnila se jeho lokalizace z jádra do cytoplasmy. Nadexprese Daxxu chránila buňky před apoptózou, zatímco jejich citlivost k buněčné smrti byla zvýšena snížením exprese Daxxu pomocí siRNA. Snížení hladiny Daxx proteinu zcitlivělo kardiomyocyty ke spontánní apoptóze, což svědčí pro to, že tento protein může mít za fyziologických podmínek roli příznivou pro přežívání. Konečně bylo ukázáno, že DJ-1, protein zřejmě vyčleňující Daxx v jádře za podmínek oxidativního stresu a zabraňující tak jeho cytosolické translokaci, byl lokalizován pouze v cytoplasmě kardiomyocytů
dcterms:title
Daxx inhibits stress-induced apoptosis in cardiac myocytes Daxx inhibits stress-induced apoptosis in cardiac myocytes Daxx inhibuje apoptózu indukovanou stresem v kardiomyocytech
skos:prefLabel
Daxx inhibits stress-induced apoptosis in cardiac myocytes Daxx inhibits stress-induced apoptosis in cardiac myocytes Daxx inhibuje apoptózu indukovanou stresem v kardiomyocytech
skos:notation
RIV/86652036:_____/08:00325125!RIV09-AV0-86652036
n3:aktivita
n12:P n12:Z
n3:aktivity
P(GA305/07/1008), Z(AV0Z50520701)
n3:cisloPeriodika
6
n3:dodaniDat
n5:2009
n3:domaciTvurceVysledku
n11:7661665 n11:4589874 n11:9025618
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
362216
n3:idVysledku
RIV/86652036:_____/08:00325125
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Daxx; apoptosis; oxidative stress
n3:klicoveSlovo
n7:oxidative%20stress n7:apoptosis n7:Daxx
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[95CB35BC15F4]
n3:nazevZdroje
Redox Report
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n4:GA305%2F07%2F1008
n3:rokUplatneniVysledku
n5:2008
n3:svazekPeriodika
13
n3:tvurceVysledku
Chladová, Jaromíra Neužil, Jiří Zobalová, Renata Dong, L. F. Swettenham, E.
n3:zamer
n15:AV0Z50520701
s:issn
1351-0002
s:numberOfPages
8