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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F15%3A00010725%21RIV15-TA0-75010330
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0378517315000897
dcterms:description
The aim of the study was the comparison of photo-activity of three types of titanium dioxide (TiO2) micro-dispersions intended for use as UV filters for cosmetic sunscreen products. The dispersions were also investigated with regard to their influence on the stability of photo-protective systems in cosmetic emulsions, their skin penetration/absorption and their photo-toxicity for humans and skin bacterial flora. All the tested micro-dispersions of rutile TiO2 type (agglomerates with diameter 120-150 nm), with primary particle size lower than 100 nm, demonstrated no phototoxic effect and insignificant antimicrobial behaviour. On the other hand, TiO2 with insufficient deactivation of photo-activity had significant negative impact on the stability of other organic UV filters and therefore on the stability of declared UV protective factors (SPF, UVA-PF). The study demonstrated that the level of deactivation of TiO2 is one of the highly important factors for evaluation of UV filters used as sunscreens. The aim of the study was the comparison of photo-activity of three types of titanium dioxide (TiO2) micro-dispersions intended for use as UV filters for cosmetic sunscreen products. The dispersions were also investigated with regard to their influence on the stability of photo-protective systems in cosmetic emulsions, their skin penetration/absorption and their photo-toxicity for humans and skin bacterial flora. All the tested micro-dispersions of rutile TiO2 type (agglomerates with diameter 120-150 nm), with primary particle size lower than 100 nm, demonstrated no phototoxic effect and insignificant antimicrobial behaviour. On the other hand, TiO2 with insufficient deactivation of photo-activity had significant negative impact on the stability of other organic UV filters and therefore on the stability of declared UV protective factors (SPF, UVA-PF). The study demonstrated that the level of deactivation of TiO2 is one of the highly important factors for evaluation of UV filters used as sunscreens.
dcterms:title
Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations
skos:prefLabel
Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations Characteristics of titanium dioxide microdispersions with different photo-activity suitable for sunscreen formulations
skos:notation
RIV/75010330:_____/15:00010725!RIV15-TA0-75010330
n3:aktivita
n7:P
n3:aktivity
P(NT14060), P(TA01010613)
n3:cisloPeriodika
1-2
n3:dodaniDat
n15:2015
n3:domaciTvurceVysledku
n8:9962999 n8:1106848 n8:7955332 n8:2358034 n8:8964297 n8:4173694
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
62
n3:idVysledku
RIV/75010330:_____/15:00010725
n3:jazykVysledku
n10:eng
n3:klicovaSlova
UV radiation; UV filter; titanium dioxide; phototoxicity; microdispersion
n3:klicoveSlovo
n4:phototoxicity n4:UV%20radiation n4:titanium%20dioxide n4:microdispersion n4:UV%20filter
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[8A94D3F559B1]
n3:nazevZdroje
International Journal of Pharmaceutics
n3:obor
n17:DN
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
10
n3:projekt
n6:TA01010613 n6:NT14060
n3:rokUplatneniVysledku
n15:2015
n3:svazekPeriodika
481
n3:tvurceVysledku
Klánová, Kateřina Bendová, Hana Hladíková, Zuzana Kovaříková, L. Pikal, P. Kejlová, Kristina Akrman, J. Jírová, Dagmar Kašparová, Lucie Kubáč, L.
n3:wos
000350453600012
s:issn
0378-5173
s:numberOfPages
6
n19:doi
10.1016/j.ijpharm.2015.02.004