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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F12%3A00009882%21RIV13-GA0-75010330
rdf:type
skos:Concept n13:Vysledek
dcterms:description
A functionally n gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in tumours. In addition to the presence of somatic mutations, polymorphic features of the gene may also contribute to alteration of the normal TP53 functioning and variants, mainly in the form of single nucleotide polymorphisms, can be expected to impact susceptibility to sporadic CRC. In the present study, we reviewed the potential role of alterations in the TP53 gene, both somatic mutations and inherited sequence variations, in predisposition to CRC and in the prognosis and response to therapy. The available data from association studies have mostly shown contradictory outcomes. The majority of the studies were based on limited sample sizes and focussed on a limited number of polymorphisms, with main b. A functionally n gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in tumours. In addition to the presence of somatic mutations, polymorphic features of the gene may also contribute to alteration of the normal TP53 functioning and variants, mainly in the form of single nucleotide polymorphisms, can be expected to impact susceptibility to sporadic CRC. In the present study, we reviewed the potential role of alterations in the TP53 gene, both somatic mutations and inherited sequence variations, in predisposition to CRC and in the prognosis and response to therapy. The available data from association studies have mostly shown contradictory outcomes. The majority of the studies were based on limited sample sizes and focussed on a limited number of polymorphisms, with main b.
dcterms:title
Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer
skos:prefLabel
Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer
skos:notation
RIV/75010330:_____/12:00009882!RIV13-GA0-75010330
n13:predkladatel
n14:ico%3A75010330
n4:aktivita
n5:Z n5:I n5:P
n4:aktivity
I, P(GAP304/10/1286), P(GP305/09/P194), Z(AV0Z50390512)
n4:cisloPeriodika
2
n4:dodaniDat
n8:2013
n4:domaciTvurceVysledku
n16:5013690
n4:druhVysledku
n18:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
152547
n4:idVysledku
RIV/75010330:_____/12:00009882
n4:jazykVysledku
n15:eng
n4:klicovaSlova
genetic polymorphisms; TP53 gene; colorectal cancer
n4:klicoveSlovo
n9:genetic%20polymorphisms n9:TP53%20gene n9:colorectal%20cancer
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[A27A600F65AE]
n4:nazevZdroje
Mutagenesis
n4:obor
n17:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:projekt
n19:GAP304%2F10%2F1286 n19:GP305%2F09%2FP194
n4:rokUplatneniVysledku
n8:2012
n4:svazekPeriodika
27
n4:tvurceVysledku
Vodičková, Ludmila Poláková, V. Hemminki, K. Vodička, P. Pardini, B. Kumar, R. Naccarati, A.
n4:wos
000300040200010
n4:zamer
n6:AV0Z50390512
s:issn
0267-8357
s:numberOfPages
8
n7:doi
10.1093/mutage/ger067