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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F12%3A00009838%21RIV13-GA0-75010330
rdf:type
skos:Concept n18:Vysledek
dcterms:description
For the first time, we have evaluated both base and nucleotide excision repair capacities in human colon biopsies to study their participation in colorectal tumorigenesis. Our complex analysis showed that tumor cells are not deficient in studied pathways, but rather follow patterns characteristic for each individual and are comparable with adjacent tissue. This study further shows the feasibility of DRC evaluation in human solid tissues, representing a complex marker of multigene DNA repair processes. For the first time, we have evaluated both base and nucleotide excision repair capacities in human colon biopsies to study their participation in colorectal tumorigenesis. Our complex analysis showed that tumor cells are not deficient in studied pathways, but rather follow patterns characteristic for each individual and are comparable with adjacent tissue. This study further shows the feasibility of DRC evaluation in human solid tissues, representing a complex marker of multigene DNA repair processes.
dcterms:title
Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas
skos:prefLabel
Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas
skos:notation
RIV/75010330:_____/12:00009838!RIV13-GA0-75010330
n18:predkladatel
n19:ico%3A75010330
n3:aktivita
n8:P n8:I n8:N n8:Z
n3:aktivity
I, N, P(GAP304/10/1286), P(GAP304/12/1585), P(NT12025), Z(AV0Z50390512)
n3:cisloPeriodika
21
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n13:5013690 n13:4078829
n3:druhVysledku
n5:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
137378
n3:idVysledku
RIV/75010330:_____/12:00009838
n3:jazykVysledku
n20:eng
n3:klicovaSlova
colorectal cancer; DNA repair
n3:klicoveSlovo
n9:DNA%20repair n9:colorectal%20cancer
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E7B66CE907F5]
n3:nazevZdroje
Clinical cancer research
n3:obor
n7:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
15
n3:projekt
n4:NT12025 n4:GAP304%2F10%2F1286 n4:GAP304%2F12%2F1585
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
18
n3:tvurceVysledku
Švec, J. Slýšková, J. Vodička, P. Liška, V. Lipská, L. Souček, Pavel Vodičková, Ludmila Collins, A. R. Schneiderová, M. Kumar, R. Naccarati, A. Korenková, V. Levý, M. Procházka, P. Holubec, L.
n3:wos
000312020400008
n3:zamer
n17:AV0Z50390512
s:issn
1078-0432
s:numberOfPages
10
n16:doi
10.1158/1078-0432.CCR-12-1380