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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F12%3A00009764%21RIV13-MZ0-75010330
rdf:type
n16:Vysledek skos:Concept
dcterms:description
The main objectives of the workshop were: - to present %22in use%22 experience of the pharmaceutical industry with the 3T3 Neutral Red Uptake Phototoxicity Test (3T3 NRU-PT), - to discuss why it differs from the results in the original validation exercise, - to discuss technical issues and consider ways to improve the usability of the 3T3 NRU-PT for (non-topical) pharmaceuticals, e.g., by modifying the threshold of chemical light absorption to trigger photo-toxicological testing, and by modifying technical aspects of the assay, or adjusting the criteria used to classify a positive response. The main objectives of the workshop were: - to present %22in use%22 experience of the pharmaceutical industry with the 3T3 Neutral Red Uptake Phototoxicity Test (3T3 NRU-PT), - to discuss why it differs from the results in the original validation exercise, - to discuss technical issues and consider ways to improve the usability of the 3T3 NRU-PT for (non-topical) pharmaceuticals, e.g., by modifying the threshold of chemical light absorption to trigger photo-toxicological testing, and by modifying technical aspects of the assay, or adjusting the criteria used to classify a positive response.
dcterms:title
The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop
skos:prefLabel
The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing - the report of an ECVAM-EFPIA workshop
skos:notation
RIV/75010330:_____/12:00009764!RIV13-MZ0-75010330
n16:predkladatel
n17:ico%3A75010330
n3:aktivita
n6:V
n3:aktivity
V
n3:cisloPeriodika
3
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n4:8964297
n3:druhVysledku
n12:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
183453
n3:idVysledku
RIV/75010330:_____/12:00009764
n3:jazykVysledku
n11:eng
n3:klicovaSlova
phototoxicity; in vitro; in vivo; testing; workshop
n3:klicoveSlovo
n8:testing n8:in%20vitro n8:in%20vivo n8:phototoxicity n8:workshop
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[8F7400615C79]
n3:nazevZdroje
Regulatory toxicology and pharmacology
n3:obor
n7:FM
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
35
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
63
n3:tvurceVysledku
Zuang, V. Jacobs, A. Tellner, P. Gibbs, N. K. Learn, D. Frank Nash, J. Muster, W. Pfannenbecker, U. Kinyamu Akunda, J. DeSmedt, A. van de Water, F. Wilcox, P. Alépée, R. Fellows, M. D. Corvi, R. Lynch, A. M. Kandárová, H. Bauer, D. Woods, J. Liebsch, M. Rogiers, V. Jones, D. Krul, C. Barroso, J. Nakamura, K. Wändel Liminga, U. Vohr, H. W. Wattrelos, O. Phillips, G. Kreysa, J. Robles, C. Jírová, Dagmar Kasper, P. Ceridono, M. Heisler, E.
n3:wos
000306885800015
s:issn
0273-2300
s:numberOfPages
9
n14:doi
10.1016/j.yrtph.2012.06.001