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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F12%3A00009720%21RIV13-GA0-75010330
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role in the development of resistance by the efflux of anticancer agents outside of cancer cells. The aim of this study was to explore transcript levels of all human ABCs in tumours and non-neoplastic control tissues from CRC patients collected before the first line of treatment by 5-fluorouracil (5-FU)-containing regimen. The prognostic potential of ABCs was evaluated by the correlation of transcript levels with clinical factors. Relations between transcript levels of ABCs in tumours and chemotherapy efficacy were also addressed. The transcript profile of all known human ABCs was assessed using real-time polymerase chain reaction with a relative standard curve. The majority. Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited by the inter-individual variability in drug response and the development of cancer cell resistance. ATP-binding cassette (ABC) transporters play a crucial role in the development of resistance by the efflux of anticancer agents outside of cancer cells. The aim of this study was to explore transcript levels of all human ABCs in tumours and non-neoplastic control tissues from CRC patients collected before the first line of treatment by 5-fluorouracil (5-FU)-containing regimen. The prognostic potential of ABCs was evaluated by the correlation of transcript levels with clinical factors. Relations between transcript levels of ABCs in tumours and chemotherapy efficacy were also addressed. The transcript profile of all known human ABCs was assessed using real-time polymerase chain reaction with a relative standard curve. The majority.
dcterms:title
The role of ABC transporters in progression and clinical outcome of colorectal cancer The role of ABC transporters in progression and clinical outcome of colorectal cancer
skos:prefLabel
The role of ABC transporters in progression and clinical outcome of colorectal cancer The role of ABC transporters in progression and clinical outcome of colorectal cancer
skos:notation
RIV/75010330:_____/12:00009720!RIV13-GA0-75010330
n5:predkladatel
n12:ico%3A75010330
n3:aktivita
n15:Z n15:S n15:P
n3:aktivity
P(GA310/07/1430), P(NS10230), S, Z(AV0Z50390512)
n3:cisloPeriodika
2
n3:dodaniDat
n17:2013
n3:domaciTvurceVysledku
n4:4078829 n4:4496736 n4:9595007 n4:2537354
n3:druhVysledku
n19:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
165963
n3:idVysledku
RIV/75010330:_____/12:00009720
n3:jazykVysledku
n6:eng
n3:klicovaSlova
colorectal cancer; ABC transporters
n3:klicoveSlovo
n16:ABC%20transporters n16:colorectal%20cancer
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[977EA6FB6A2E]
n3:nazevZdroje
Mutagenesis
n3:obor
n20:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
12
n3:projekt
n8:NS10230 n8:GA310%2F07%2F1430
n3:rokUplatneniVysledku
n17:2012
n3:svazekPeriodika
27
n3:tvurceVysledku
Piťule, P. Mohelníková-Duchoňová, Beatrice Bruha, J. Souček, Pavel Holubec, L. Novák, P. Vyčítal, O. Hlavatá, Ivona Vodička, P. Liška, V. Václavíková, Radka Třeška, V.
n3:wos
000300040200007
n3:zamer
n10:AV0Z50390512
s:issn
0267-8357
s:numberOfPages
10
n13:doi
10.1093/mutage/ger075