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Statements

Subject Item
n2:RIV%2F75010330%3A_____%2F12%3A00009618%21RIV13-MZ0-75010330
rdf:type
skos:Concept n8:Vysledek
dcterms:description
Associations of ctional single nucleotide polymorphisms (SNPs) rs4880, rs1799895, rs2536512, rs699473, rs1800566 and rs1143684 with prognosis of breast cancer patients were studied. SNPs were assessed by allelic discrimination in a cohort of 321 breast cancer patients from the Czech Republic. Transcript levels were determined by real-time polymerase chain reaction (PCR) with absolute quantification in tumor and adjacent non-neoplastic control tissues. Both genotypes and transcript levels were then compared with available clinical data on patients. Patients carrying low activity allele Leu in NQO2 rs1143684 had a greater incidence of stage 0 or I disease (i.e., better prognosis) than patients with the Phe/Phe genotype. This association was more evident in patients without expression of progesterone receptors (p = 0.031). Patients carrying the Thr allele in SOD3 rs2536512 SNP had a significantly greater incidence of tumors expressing estrogen receptors than patients carrying the Ala/Ala genotype (p = 0. Associations of ctional single nucleotide polymorphisms (SNPs) rs4880, rs1799895, rs2536512, rs699473, rs1800566 and rs1143684 with prognosis of breast cancer patients were studied. SNPs were assessed by allelic discrimination in a cohort of 321 breast cancer patients from the Czech Republic. Transcript levels were determined by real-time polymerase chain reaction (PCR) with absolute quantification in tumor and adjacent non-neoplastic control tissues. Both genotypes and transcript levels were then compared with available clinical data on patients. Patients carrying low activity allele Leu in NQO2 rs1143684 had a greater incidence of stage 0 or I disease (i.e., better prognosis) than patients with the Phe/Phe genotype. This association was more evident in patients without expression of progesterone receptors (p = 0.031). Patients carrying the Thr allele in SOD3 rs2536512 SNP had a significantly greater incidence of tumors expressing estrogen receptors than patients carrying the Ala/Ala genotype (p = 0.
dcterms:title
Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas
skos:prefLabel
Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas
skos:notation
RIV/75010330:_____/12:00009618!RIV13-MZ0-75010330
n8:predkladatel
n9:ico%3A75010330
n3:aktivita
n12:Z n12:I n12:S n12:P
n3:aktivity
I, P(NS9799), S, Z(MZ0FNM2005)
n3:cisloPeriodika
2
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n10:4496736 n10:3552942 n10:8062587 n10:7020597 n10:5997488 n10:4078829
n3:druhVysledku
n20:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
123916
n3:idVysledku
RIV/75010330:_____/12:00009618
n3:jazykVysledku
n18:eng
n3:klicovaSlova
breast cancer; breast; cancer; quinones; oxidoreductase; prognosis
n3:klicoveSlovo
n7:cancer n7:prognosis n7:breast n7:breast%20cancer n7:oxidoreductase n7:quinones
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[D87C545C8722]
n3:nazevZdroje
International journal of cancer
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:projekt
n16:NS9799
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
130
n3:tvurceVysledku
Gut, Ivan Souček, Pavel Kodet, R. Ehrlichová, Marie Hubáčková, Miluše Kubáčková, K. Vrána, David Mrhalová, M. Václavíková, Radka
n3:wos
000298254400011
n3:zamer
n13:MZ0FNM2005
s:issn
0020-7136
s:numberOfPages
11
n19:doi
10.1002/ijc.26006